EXECUTIVE SUMMARY - GOLD

pulmonary disease. Department of Veterans
Affairs Cooperative Study Group. N Engl J
Med 1999;340(25):1941-7.
224. Maltais F, Ostinelli J, Bourbeau J, Tonnel
AB, Jacquemet N, Haddon J, et al.
Comparison of nebulized budesonide and oral
prednisolone with placebo in the treatment of
acute exacerbations of chronic obstructive
pulmonary disease: a randomised controlled
trial. Am J Respir Crit Care Med
2002;165(5):698-703.
225. Aaron SD, Vandemheen KL, Hebert P,
Dales R, Stiell IG, Ahuja J, et al. Outpatient
oral prednisone after emergency treatment of
chronic obstructive pulmonary disease. N
Engl J Med 2003;348(26):2618-25.
226. Rodriguez-Roisin R. COPD
exacerbations.5: management. Thorax
2006;61(6):535-44.
227. Connors AF, Jr., Dawson NV, Thomas C,
Harrell FE, Jr., Desbiens N, Fulkerson WJ, et
al. Outcomes following acute exacerbation of
severe chronic obstructive lung disease. The
SUPPORT investigators (Study to Understand
Prognoses and Preferences for Outcomes and
Risks of Treatments). Am J Respir Crit Care
Med 1996;154(4 Pt 1):959-67.
228. Shepperd S, Harwood D, Gray A, Vessey
M, Morgan P. Randomised controlled trial
comparing hospital at home care with
inpatient hospital care. II: cost minimisation
analysis. BMJ 1998;316(7147):1791-6.
229. Gravil JH, Al-Rawas OA, Cotton MM,
Flanigan U, Irwin A, Stevenson RD. Home
treatment of exacerbations of chronic
obstructive pulmonary disease by an acute
respiratory assessment service. Lancet
1998;351(9119):1853-5.
230. Soderstrom L, Tousignant P, Kaufman T.
The health and cost effects of substituting
home care for inpatient acute care: a review of
the evidence. CMAJ 1999;160(8):1151-5.
231. National Institute for Clinical Excellence
(NICE). Chronic obstructive pulmonary
disease. National clinical guideline on
management of chronic obstructive
pulmonary disease in adults in primary and
secondary care. Thorax 2004;59 Suppl 1:1-
232.
232. Barbera JA, Reyes A, Roca J, Montserrat
JM, Wagner PD, Rodriguez-Roisin R. Effect
of intravenously administered aminophylline
on ventilation/perfusion inequality during
recovery from exacerbations of chronic
obstructive pulmonary disease. Am Rev
Respir Dis 1992;145(6):1328-33.
233. Mahon JL, Laupacis A, Hodder RV,
McKim DA, Paterson NA, Wood TE, et al.
Theophylline for irreversible chronic airflow
limitation: a randomised study comparing n of
1 trials to standard practice. Chest
1999;115(1):38-48.
234. Lloberes P, Ramis L, Montserrat JM,
Serra J, Campistol J, Picado C, et al. Effect of
three different bronchodilators during an
exacerbation of chronic obstructive
pulmonary disease. Eur Respir J
1988;1(6):536-9.
235. Murciano D, Aubier M, Lecocguic Y,
Pariente R. Effects of theophylline on
diaphragmatic strength and fatigue in patients
with chronic obstructive pulmonary disease.
N Engl J Med 1984;311(6):349-53.