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Randomized trial on the efficacy of two non steroidal drugs in the prevention of skin damage induced by radiotherapy 3. James D Cox MD, Jo Ann Stetz BS, Thomas F Pajak. Toxicity Criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiation Oncology Biol Phys 1995; 31:1341-1346. 4. National Cancer Institute, Cancer Therapy Evaluation program: “Common Toxicity Criteria Manual, Version 2.0 June 1, 1999”. 5. Perez CA, Kutcher GJ, Emami B, et al. Fitting normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1999; 44:855-886. 6. Tucker S, Turesson I, Thames H. Evidence of individual differences in the radiosensitivity of human skin. Int J Radiat Oncol Biol Phys 1984; 10:607-18. 7. Wickline MM. Prevention and treatment of acute radiation dermatitis: a literature review. Oncol Nurs Forum 2004; 31:237-47. 8. Richardson J, Smith JE, McIntyre M, Thomas R, Pilkington K. Aloe vera for preventing radiation-induced skin reactions: a systematic literature review. Clin Oncol (R Coll Radiol) 2005; 17:478-84. 9. Bolderston A, Lloyd NS, Wong RK, Holden L, Robb- B l e n d e rma n L. Supportive Care Guidelines Group of Cancer C a re Ontario Program in Evidence-Based Care. The pre v e n- tion and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline. Support Care Cancer 14:802-17. Epub 2006. 10. McQuestion M. Evidence-based skin care management in radiation therapy. Semin Oncol Nurs 2006; 22:163-73. 11. Röper B, Kaisig D, Auer F, Mergen E, Molls M. Thêta- Cream versus Bepanthol lotion in breast cancer patients under radiotherapy. A new prophylactic agent in skin care? Strahlenther Onkol 2004; 180:315-22. 12. Pommier P, Gomez F, Sunyach MP, et al. Phase III randomized trial of Calendula Officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol 2004; 22:1447-1453. 13. Szumacher E, Wighton A, Franssen E, et al. Phase II study assessing the effectiveness of Biafine cream as a prophylactic agent for radiation-induced acute skin toxicity to the breast in women undergoing radiotherapy with concomitant CMF chemotherapy. IJROBP 2001; 51:81-6. 14. Fisher J, Scott C, Stevens R, et al. Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13. Int J Radiat Oncol Biol Phys 2000; 48:1307-1. 15. Leonardi MC, Gariboldi S, Ivaldi GB, et al. A doubleblind, randomised, vehicle-controlled clinical study to evaluate the efficacy of MAS065D in limiting the effects of radiation on the skin: interim analysis. Eur J Dermatol 2008; 18:317-21. 16. Wells M, Macmillan M, Raab G, et al. Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial. Radiother Oncol 2004; 73:153-62. 17. Richardson J, Smith JE, McIntyre M, et al. Aloe vera for p reventing radiation-induced skin reactions: a systematic lite r a t u re re v i e w. Clin Oncol (R Coll Radiol) 2005; 17:478-84. 18. AIRO-ESTRO: Assicurazione di qualità in Radioterapia. Quality Assurance in Radiotherapy. Omicron Coop. Ed. Genova, 1997. Journal of Plastic Dermatology 2009; 5, 3 239
Clinical evaluation of a nutraceutical containing lycopene, soy isophlavones and vitamin C on the performance and duration of an intradermal filler Adele Sparavigna SU M M A R Y Clinical evaluation of a nutraceutical containing lycopene, soy isophlavones and vitamin C on the performance and duration of an intradermal filler Aim of the study was to evaluate, clinically and by non-invasive instrumental evaluations, the efficacy and the tolerance of an intradermal filler associated to food supplement on principal ageing/photoageing skin signs. 26 female healthy volunteers were enrolled. They were divided into 2 groups. Group I (subjects performing intradermal implants with dermal filler associated to Innéov Re-Age Fermeté food supplement). Group II (subjects performing only intradermal implants with High Fill). The study duration was 28 weeks with 5 control visits. During the visits the following clinical and instrumental evaluations were performed: wrinkles grade at level of nasolabial folds and around the eyes, surface microrelief at level of the cheek, skin tonicity, skin brightness, skin replicas at level of nasolabial folds for wrinkles profilometric evaluation. Clinical and instrumental evaluations confirmed the antiage activity of “Innéov Re- Age Fermeté and demonstrated as the food supplement increased the efficacy of the “High Fill” intradermal filler. Treatment tolerance was optimal (final investigators’ judgement: 100% = good-excellent); in fact no adverse event related to the tested products occurred during the entire study period. KE Y W O R D S: I n t r a d e rmal filler; Food supplementation DermIng, Clinical Research and Bioengineering Institute, Monza. I Introduction In recent years several studies have demonstrated that certain dietary supplements can exert beneficial effects on skin ageing. Nutraceuticals are mainly natural products that are used to supplement the diet by increasing the total dietary intake of important nutrients targeting a particular skin benefit. The interest of the dermatologist regarding the correlation between diet, wellness and skin healthiness has stimulated the discussion about the evaluation of the possible benefits. It is also a requirement by law that claimed skin benefits are substantiated by scientific evidence. Generally speaking, oral skin supplements are not expected to work entirely on their own: they can be considered beneficial when used in conjunction with traditional skin care regimens and a healthy diet. For example, taking a “beauty pill” shouldn’t encourage smoking or excessive sun exposure. A further step in oral supplementation for dermatological prescription is to support skin medical treatment effect. Aim of the present study was to verify the possibility that a specific product designed to improve skin firmness Journal of Plastic Dermatology 2009; 5, 3 241
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Obiettivo della rivista Il Journal
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