Vol. 5, n. 3, September-December 2009 - Salute per tutti

Clinical evaluation of a nutraceutical
containing lycopene, soy isophlavones
and vitamin C on the performance
and duration of an intradermal filler
Adele Sparavigna
SU M M A R Y
Clinical evaluation of a nutraceutical
containing lycopene, soy isophlavones
and vitamin C on the performance
and duration of an intradermal filler
Aim of the study was to evaluate, clinically and by non-invasive instrumental evaluations,
the efficacy and the tolerance of an intradermal filler associated to food supplement
on principal ageing/photoageing skin signs. 26 female healthy volunteers
were enrolled. They were divided into 2 groups.
Group I (subjects performing intradermal implants with dermal filler associated to
Innéov Re-Age Fermeté food supplement). Group II (subjects performing only intradermal
implants with High Fill).
The study duration was 28 weeks with 5 control visits. During the visits the following
clinical and instrumental evaluations were performed: wrinkles grade at level of
nasolabial folds and around the eyes, surface microrelief at level of the cheek, skin
tonicity, skin brightness, skin replicas at level of nasolabial folds for wrinkles profilometric
evaluation.
Clinical and instrumental evaluations confirmed the antiage activity of “Innéov Re-
Age Fermeté and demonstrated as the food supplement increased the efficacy of the
“High Fill” intradermal filler. Treatment tolerance was optimal (final investigators’
judgement: 100% = good-excellent); in fact no adverse event related to the tested
products occurred during the entire study period.
KE Y W O R D S: I n t r a d e rmal filler; Food supplementation
DermIng, Clinical Research
and Bioengineering Institute, Monza.
I Introduction
In recent years several studies have
demonstrated that certain dietary supplements
can exert beneficial effects on skin ageing.
Nutraceuticals are mainly natural products that
are used to supplement the diet by increasing
the total dietary intake of important nutrients
targeting a particular skin benefit. The interest
of the dermatologist regarding the correlation
between diet, wellness and skin healthiness has
stimulated the discussion about the evaluation
of the possible benefits. It is also a requirement
by law that claimed skin benefits are substantiated
by scientific evidence. Generally speaking,
oral skin supplements are not expected to work
entirely on their own: they can be considered
beneficial when used in conjunction with traditional
skin care regimens and a healthy diet. For
example, taking a “beauty pill” shouldn’t
encourage smoking or excessive sun exposure.
A further step in oral supplementation for dermatological
prescription is to support skin
medical treatment effect. Aim of the present
study was to verify the possibility that a specific
product designed to improve skin firmness
Journal of Plastic Dermatology 2009; 5, 3 241