Autoreferat finalizat spre tipar 02.03.2012

ANNOTATION
PETROVICI Vergil
„Clinical and morphological peculiarities of liver hydatidosis in children”
PhD thesis. Chisinau, 2012.
Thesis structure: The dissertation paper consists of 170 pages that include: introduction, six
chapters, conclusions, practical recommendations, bibliography what includes 228 sources, 120
pages of basic text, 10 tables, 117 figures. The results were published in 20 scientific works
including 1 monograph.
Key words: echinococcosis, liver cystic hydatidosis, pathological anatomy, children.
Field of research: pathological anatomy
The aim and objectives of the study. Establishing the pathological peculiarities of liver cystic
hydatidosis in children and the morpho-functional changes in relation of the vital activity of the
parasite, and evolutionary forms of the disease, the associated complications and recurrences.
Objectives: the study of morphological peculiarities of hydatid cyst depending on disease types
and the on vital activity of larval cyst; assessment of scolecide drugs; research of changes of
hepatocellular and immunocellular components in hydatid lesions; elucidation of peculiarities in
hepatic parenchyma at distance of the cysts.
Scientific novelty of the work. For the first time, were established some sequence peculiarities
of pathological changes of liver hydatid cyst in children with the elucidation of structural,
biological and germinative components of the parasite; was confirmed the efficacy of scolecide
drugs and the antagonistic relationships in coinfection, was argued etiopathogenic features of
vascularization in pericystic area and of changes in hepatic parenchyma at diverse distance of the
cysts. Scientific problem solved. Establishment of hepatic hydatid cyst morphogenesis in
children, to define the concept of clinical-morphological evolution of hydatid cyst and hepatic
parenchymal changes at distance depending on the parasite activity, to elaborate a new strategy
of pathological diagnosis.
The theoretical significance. The study results contribute to define a modern concept and an
original vision on hydatid biology and morphogenesis in human infection.
Applicative value of the research. Applicative value of the research is a new strategy in the
methodology of pathological diagnosis in vivo of morpho-functional peculiarities in hepatic
parenchyma at distance of the cysts.
Implementation of scientific results. The research results were implemented in the work of SP
N Cin PS "Natalia Gheorghiu" and in the laboratory "Surgical infections in children» from the
SMPhU "Nicolae Testemiţanu", in clinical diagnostic work of the department of centralized
pathological anatomy and scientific polling Pathology PMSIRIMandCHC
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