KRONİK KALP YETERSİZLİĞİNDE FONKSİYONEL KAPASİTE VE ...

ABSTRACT
Plasma Level of NT-proBNP in Assessment of Functional Capacity and Prognosis in
Patients with Heart Failure
New York Heart Association (NYHA) classification is frequently used for the
assessment of functional capacity in heart failure patients. However, the classification is a
subjective method and may change according to the loading conditions. We investigated the
relation between the levels of NT-proBNP at rest and after exercise and functional capacity
and also one year mortality and/or morbidity.
One-hundred heart failure patients (88 male, 12 female and mean age: 53.6 ± 8.9
years) and 20 healthy subjects (17 male, 3 female and mean age: 51.5 ± 4.8 years) were
enrolled the study. All subjects underwent echocardiography and exercise test. The levels of
NT-proBNP were measured at rest and after exercise. The patients were followed up 420 ± 45
days.
The level of NT-proBNP at rest and left atrium diastolic dimension were the most
important parameters in predicting functional capacity (p1570 and those with ≤1569 pg/ml, respectively.
In conclusion, NT-proBNP is an easy and reliable parameter in predicting functional
capacity and mortality and/or morbidity in patients with heart failure.
morbidity
Keywords: NT-proBNP, Heart failure, Functional capacity, Mortality and/or
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