January 2006 (PDF 2.9 MB) - Barrick Gold Corporation

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For Sodium Cyanide (solid):
Oral LD50 (rat): 6.4 mg/kg; Oral Lowest Lethal Dose (human): 2.9 mg/kg (4)
Ocular LD50 (rabbit): 5.0 mg/kg (4)
For Hydrogen Cyanide (gas) -
Oral LD50 (mouse): 3.7 mg/kg (4)
Inhalation LC50 (rat): 160 ppm/30 min (4)
Inhalation Lowest Lethal Concentration (human): 120 mg/m3/1 hr (4)
Inhalation Lowest Lethal Concentration (human): 200 mg/m3/10 min (4)
Inhalation Lowest Lethal Concentration (human): 400 mg/m3/2 min (4)
Ocular LD50 (rabbit): 1.0 mg/kg (4)
No signs of cyanide toxicity were observed in a 2 year feeding study
in rats given food containing 100 and 300 ppm of hydrogen cyanide. (5)
The high toxicity of cyanide compounds results from their ability to
interfere with the body’s utilisation of oxygen at the cellular level
by inhibiting the cytochrome oxidase enzyme system (1,3)
In a study of the effect of chronic cyanide exposure at up to twice the
current recommended exposure standard (ie 6.4 to 10.4 ppm) (6)
. No signs of hypo- or hyperthyroidism.
. 56% of the workers had thyroid enlargement to a mild or moderate
degree.
. Workers were exposed to other chemicals.
. There was no association between the period of exposure and the
incidence of enlargement or size of the thyroid.
12. ECOLOGICAL INFORMATION
Avoid contaminating waterways. Very toxic to aquatic organisms.
For Hydrogen Cyanide - (7)
96 hr LC50 (rainbow trout): 57 ug/L
TLm 24 (sunfish): 0.18 mg/L
TLm 24 (pinperch): 0.05 mg/L in sea water
TLm 24: Median Tolerance Limit - the concentration of toxicant or
substance at which 50% of the test organisms survive over a 24 hour test
period.
13. DISPOSAL CONSIDERATIONS
Refer to State/Territory Land Waste Management Authority. Waste treatment is essential. Empty containers
must be decontaminated and destroyed. Dispose of material through a licensed waste contractor.
14. TRANSPORT INFORMATION
Classified as Dangerous Goods by the criteria of the Australian Dangerous Goods Code (ADG Code) for
transport by road or rail.
UN-No: 1935
Class: 6.1 Toxic
Product name: Sodium Cyanide Solution - (30% w/w) Substance Key: 000033640201
Issued: 27.01.2000 Version: 1.3 Page: 7 of 9