Sve~ana akademija - Drustvo Srbije za borbu protiv raka

Najzna~ajnije delo \or|a Joannovi}a,
malo poznato je, da je bio svetski pionir
u otkri}u procesa autoagresije u medicini.
U to vreme je u medicini vladala dogma
inaugurisana od nobelovca imunologa
Paula Erliha, pronalaza~a leka salvarzana
protiv sifilisa, koji je bio prijateq
\or|a Joannovi}a da „organizam
nikada ne stvara materije protiv samog
sebe”.
Danas u XXI veku mi znamo da to nije
ta~no, jer ve} na }elijskom nivou organizam
{aqe molekul smrti svojim nepotrebnim
}elijama, koji onda aktivira u }eliji
ve} ugra|eni kaspazni sistem enzima, a
koji „isecka” DNK i dovodi do samoubistva
}elija tj. apoptoze.
Tako|e, danas znamo da postoje mnoge
autoimune bolesti.
Me|utim, tada je \or|e Joannovi}
zapazio da vojnici koji su imali izle~enu
povredu glave i mozga nanetu vatrenim
oru`jem nekada imaju nesnosne glavoboqe
i neki takvi vojnici umiru.
Na obdukcijama takvih bolesnika
nalaze se samo multipna ogwi{ta razmek{awa
mozga, kako u blizini, tako i u
daqem odstojawu od izle~ene povrede
mozga.
Iste rezultate je dobio i svojim
eksperimentima na belim pacovima koji
su izlagani udarima povre|ivawa glave.
Iz ovih zapa`awa na qudima i `ivotiwama
\or|e Joannovi} izvla~i genijalni
zakqu~ak: „Isti elementi mozga, koji su
usled traume bili izvor za mno`ewe produkata
raspada podle`u kasnije dejstvu
svojih reakcionih produkata”.
Ako ovo prevedemo na dana{wi jezik o
autoagresiji, o~igledno raspadni produkti
mozga stimuli{u na{ imuni sistem da
stvori antitela protiv wih, ali i protiv
takvih materija u zdravim }elijama mozga
i otuda multiple encefalomalacije.
\or|e Joannovi} je ~ak poku{ao da
primeni ovaj svoj koncept u terapiji karcinoma
ko`e qudi i tuberkuloznih granuloma
kod `ivotiwa ubrizgavaju}i „ra-
{~ine” (misli na raspadne produkte ovih
oboqewa) pod ko`u takvih bolesnika i
eksperimentalnih `ivotiwa.
experimental oncology and pathology as well
as pathologic morphology.
It is particularly important for us that he
was the first Serbian oncologist/scientist.
The most important scientific achievement
of Djor|e Joannovi} is a little known
fact that he was a pioneer in the discovery of
autoagression in medicine.
At that time in the medical circles dominated
a narrow dogma inaugurated by the
Nobel Prize Laureate, Immunologist Paul
Ehrlich, inventor of "Salvarsan", a medicine
against syphilis, who was a friend of \or|e
Joannovi}, that the "human organism never
creates substances against itself".
Today, in the 21st century, we know that it
is not true, for already at the cell level the
organism sends a death molecule to its
unnecessary cells, which then activates in the
cell already built-in caspase enzyme system
that cuts the DNA and leads to cell suicide or
apoptosis.
Furthermore, we are aware today that
there are many autoimmune diseases.
However, \or|e Joannovi} noticed then
that the soldiers with healed firearm-related
head and brain injuries sometimes had heavy
headaches and died.
Autopsy of such patients proved multiple
areas of softened brain tissue, both in the
vicinity and at a longer distance from the
healed brain injury.
He got the same results in his experiments
on white rats which were subjected to head
injuries.
From such human and animal observation
\or|e Joannovi} drew a brilliant conclusion:
"The same brain elements, which have been
as result of trauma source for multiplication
of products of disintegration, later on are subject
to action of their reaction products".
If we interpret this into today's language
of autoagression, it is obvious that disintegration
brain products stimulate our immune
system to make antibodies against them, but
also against such substances in the healthy
brain cells, which causes multiple encephalomalacias.
\or|e Joannovi} even tried to apply this
concept of his in the therapy of human skin
cancer and tuberculous granuloma of animals,
injecting the disintegration tissue under
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