View/Open - Università degli Studi di Milano-Bicocca
View/Open - Università degli Studi di Milano-Bicocca
View/Open - Università degli Studi di Milano-Bicocca
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Discussion<br />
Figure 14: Model, part 2. At 25°C, the TERRA G4 structures might be unstable due to<br />
temperature me<strong>di</strong>ated intracellular changes. The lack of RIF1 increases TERRA<br />
formation and this leads to an increase amount of Cdc13-1 bound to TERRA that can<br />
titrate Cdc13-1 from the telomeric DNA. This can affect Cdc13-dependent priming of<br />
the lagging strand synthesis that causes increased telomeric ssDNA and checkpoint<br />
activation.<br />
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