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References 170. Boltz KA, Leehy K, Song X, Nelson AD, Shippen DE (2012) ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis. Mol Biol Cell 23: 1558–1568. 171. Taddei A, Gasser SM (2012) Structure and function in the budding yeast nucleus. Genetics 192: 107–129. 172. Ferreira HC, Luke B, Schober H, Kalck V, Lingner J, et al. (2011) The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast. Nature Cell Biology 13: 867–874. 173. Stower H (2012) Chromosome biology: Pairing up for the genetic exchange. Nature Reviews Genetics 13: 449–449. 174. Molenaar C, Wiesmeijer K, Verwoerd NP, Khazen S, Eils R, et al. (2003) Visualizing telomere dynamics in living mammalian cells using PNA probes. EMBO J 22: 6631–6641. 175. Chung I, Osterwald S, Deeg KI, Rippe K (2012) PML body meets telomere. Nucleus 3: 263–275. 176. Gartenberg MR (2009) Life on the edge: telomeres and persistent DNA breaks converge at the nuclear periphery. Genes Dev 23: 1027–1031. 177. Oza P, Jaspersen SL, Miele A, Dekker J, Peterson CL (2009) Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery. Genes Dev 23: 912–927. 178. Lisby M, Teixeira T, Gilson E, Géli V (2010) The fate of irreparable DNA double-strand breaks and eroded telomeres at the nuclear periphery. Nucleus 1: 158–161. 179. Ivanov EL, Sugawara N, White CI, Fabre F, Haber JE (1994) Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae. Mol Cell Biol 14: 3414–3425. 180. Clerici M, Mantiero D, Lucchini G, Longhese MP (2005) The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends. J Biol Chem 280: 38631–38638. 181. Mimitou EP, Symington LS (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455: 770–774. 182. Zhu Z, Chung W-H, Shim EY, Lee SE, Ira G (2008) Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134: 981–994. 113
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UNIVERSITÀ DEGLI STUDI DI MILANO-B
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Contents
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Abstract
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Riassunto
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Introduction
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Introduction In Saccharomyces cerev
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Introduction Figure 3: A: Diagram s
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Introduction The Replication Protei
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Introduction Rap1 C terminal is ess
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Introduction and highest at G1 phas
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Introduction cleaves the RNA strand
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Introduction In the G1 cell cycle p
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Introduction impaired, and nuclease
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Introduction functionally compromis
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Introduction increasing the interac
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Introduction Similarly in fission y
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Introduction constitutive phosphory
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Shelterin-Like Proteins and Yku Inh
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Bonetti et. al., PLoS Genet. 2010 M
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Rif1 Supports the Function of the C
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Anbalagan et. al., PLoS Genet. 2011
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Page 73 and 74: Anbalagan et. al., PLoS Genet. 2011
Page 95 and 96: References Anbalagan et. al., PLoS
Page 99: Anbalagan et. al., PLoS Genet. 2011
Page 102 and 103: Discussion The DNA damage proteins
Page 104 and 105: Discussion An hypothesis for the sp
Page 106 and 107: Discussion Figure 14: Model, part 2
Page 108 and 109: Telomeric G4 Discussion Apart from
Page 110 and 111: References 1. Hayflick L (1965) The
Page 112 and 113: References that is required for tel
Page 114 and 115: References 51. Surovtseva YV, Churi
Page 116 and 117: References telomere elongation in S
Page 118 and 119: References 100. Walker JR, Corpina
Page 120 and 121: References 124. Gravel S, Larrivée
Page 122 and 123: References 147. Lamarche BJ, Orazio
Page 126 and 127: References 194. Nimonkar AV, Ozsoy
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