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References 51. Surovtseva YV, Churikov D, Boltz KA, Song X, Lamb JC, et al. (2009) Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. Mol Cell 36: 207–218. 52. Miyake Y, Nakamura M, Nabetani A, Shimamura S, Tamura M, et al. (2009) RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to singlestranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell 36: 193–206. 53. Dai X, Huang C, Bhusari A, Sampathi S, Schubert K, et al. (2010) Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection. EMBO J 29: 2788–2801. 54. Anderson BH, Kasher PR, Mayer J, Szynkiewicz M, Jenkinson EM, et al. (2012) Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus. Nat Genet 44: 338–342. 55. Keller RB, Gagne KE, Usmani GN, Asdourian GK, Williams DA, et al. (2012) CTC1 Mutations in a patient with dyskeratosis congenita. Pediatr Blood Cancer 59: 311–314. 56. McGee JS, Phillips JA, Chan A, Sabourin M, Paeschke K, et al. (2010) Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair. Nat Struct Mol Biol 17: 1438– 1445. 57. Bühler M, Gasser SM (2009) Silent chromatin at the middle and ends: lessons from yeasts. The EMBO Journal 28: 2149–2161. 58. König P, Giraldo R, Chapman L, Rhodes D (1996) The Crystal Structure of the DNA-Binding Domain of Yeast RAP1 in Complex with Telomeric DNA. Cell 85: 125–136. 59. Liu C, Mao X, Lustig AJ (1994) Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae. Genetics 138: 1025–1040. 60. Hardy CF, Sussel L, Shore D (1992) A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev 6: 801–814. 61. Wotton D, Shore D (1997) A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev 11: 748–760. 103
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UNIVERSITÀ DEGLI STUDI DI MILANO-B
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Contents
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Abstract
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Riassunto
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Introduction
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Introduction In Saccharomyces cerev
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Introduction Figure 3: A: Diagram s
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Introduction The Replication Protei
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Introduction Rap1 C terminal is ess
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Introduction and highest at G1 phas
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Introduction cleaves the RNA strand
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Introduction In the G1 cell cycle p
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Introduction impaired, and nuclease
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Introduction functionally compromis
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Introduction increasing the interac
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Introduction Similarly in fission y
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Introduction constitutive phosphory
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Shelterin-Like Proteins and Yku Inh
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Bonetti et. al., PLoS Genet. 2010 M
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Page 63 and 64: Bonetti et. al., PLoS Genet. 2010 M
Page 65 and 66: Rif1 Supports the Function of the C
Page 67 and 68: Anbalagan et. al., PLoS Genet. 2011
Page 95 and 96: References Anbalagan et. al., PLoS
Page 99: Anbalagan et. al., PLoS Genet. 2011
Page 102 and 103: Discussion The DNA damage proteins
Page 104 and 105: Discussion An hypothesis for the sp
Page 106 and 107: Discussion Figure 14: Model, part 2
Page 108 and 109: Telomeric G4 Discussion Apart from
Page 110 and 111: References 1. Hayflick L (1965) The
Page 112 and 113: References that is required for tel
Page 116 and 117: References telomere elongation in S
Page 118 and 119: References 100. Walker JR, Corpina
Page 120 and 121: References 124. Gravel S, Larrivée
Page 122 and 123: References 147. Lamarche BJ, Orazio
Page 124 and 125: References 170. Boltz KA, Leehy K,
Page 126 and 127: References 194. Nimonkar AV, Ozsoy
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