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References that is required for telomere elongation. Nature Structural & Molecular Biology 17: 202–209. 28. Gao H, Cervantes RB, Mandell EK, Otero JH, Lundblad V (2007) RPA-like proteins mediate yeast telomere function. Nature Structural & Molecular Biology 14: 208–214. 29. Grandin N, Reed SI, Charbonneau M (1997) Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev 11: 512–527. 30. Grandin N, Damon C, Charbonneau M (2001) Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J 20: 1173–1183. 31. Garvik B, Carson M, Hartwell L (1995) Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol Cell Biol 15: 6128–6138. 32. Qi H, Zakian VA (2000) The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein. Genes Dev 14: 1777– 1788. 33. Diede SJ, Gottschling DE (1999) Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta. Cell 99: 723–733. 34. Evans SK, Lundblad V (1999) Est1 and Cdc13 as Comediators of Telomerase Access. Science 286: 117–120. 35. Chandra A, Hughes TR, Nugent CI, Lundblad V (2001) Cdc13 both positively and negatively regulates telomere replication. Genes Dev 15: 404–414. 36. Hang LE, Liu X, Cheung I, Yang Y, Zhao X (2011) SUMOylation regulates telomere length homeostasis by targeting Cdc13. Nature Structural & Molecular Biology 18: 920–926. 37. Grossi S, Puglisi A, Dmitriev PV, Lopes M, Shore D (2004) Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Genes Dev 18: 992–1006. 38. Petreaca RC, Chiu H-C, Nugent CI (2007) The Role of Stn1p in Saccharomyces cerevisiae Telomere Capping Can Be Separated From Its Interaction With Cdc13p. Genetics 177: 1459–1474. 101
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UNIVERSITÀ DEGLI STUDI DI MILANO-B
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Contents
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Abstract
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Riassunto
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Introduction
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Introduction In Saccharomyces cerev
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Introduction Figure 3: A: Diagram s
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Introduction The Replication Protei
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Introduction Rap1 C terminal is ess
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Introduction and highest at G1 phas
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Introduction cleaves the RNA strand
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Introduction In the G1 cell cycle p
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Introduction impaired, and nuclease
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Introduction functionally compromis
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Introduction increasing the interac
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Introduction Similarly in fission y
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Introduction constitutive phosphory
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Shelterin-Like Proteins and Yku Inh
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Bonetti et. al., PLoS Genet. 2010 M
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Page 61 and 62: Bonetti et. al., PLoS Genet. 2010 M
Page 63 and 64: Bonetti et. al., PLoS Genet. 2010 M
Page 65 and 66: Rif1 Supports the Function of the C
Page 67 and 68: Anbalagan et. al., PLoS Genet. 2011
Page 95 and 96: References Anbalagan et. al., PLoS
Page 99: Anbalagan et. al., PLoS Genet. 2011
Page 102 and 103: Discussion The DNA damage proteins
Page 104 and 105: Discussion An hypothesis for the sp
Page 106 and 107: Discussion Figure 14: Model, part 2
Page 108 and 109: Telomeric G4 Discussion Apart from
Page 110 and 111: References 1. Hayflick L (1965) The
Page 114 and 115: References 51. Surovtseva YV, Churi
Page 116 and 117: References telomere elongation in S
Page 118 and 119: References 100. Walker JR, Corpina
Page 120 and 121: References 124. Gravel S, Larrivée
Page 122 and 123: References 147. Lamarche BJ, Orazio
Page 124 and 125: References 170. Boltz KA, Leehy K,
Page 126 and 127: References 194. Nimonkar AV, Ozsoy
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