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References 147. Lamarche BJ, Orazio NI, Weitzman MD (2010) The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett 584: 3682–3695. 148. Schramke V, Luciano P, Brevet V, Guillot S, Corda Y, et al. (2003) RPA regulates telomerase action by providing Est1p access to chromosome ends. Nature Genetics 36: 46–54. 149. Greenwell PW, Kronmal SL, Porter SE, Gassenhuber J, Obermaier B, et al. (1995) TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82: 823–829. 150. Sabourin M, Tuzon CT, Zakian VA (2007) Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae. Mol Cell 27: 550–561. 151. Hector RE, Shtofman RL, Ray A, Chen B-R, Nyun T, et al. (2007) Tel1p preferentially associates with short telomeres to stimulate their elongation. Mol Cell 27: 851–858. 152. Mallory JC, Petes TD (2000) Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. Proc Natl Acad Sci USA 97: 13749–13754. 153. Ma Y, Greider CW (2009) Kinase-Independent Functions of TEL1 in Telomere Maintenance. Mol Cell Biol 29: 5193–5202. 154. Baldo V, Testoni V, Lucchini G, Longhese MP (2008) Dominant TEL1-hy Mutations Compensate for Mec1 Lack of Functions in the DNA Damage Response. Mol Cell Biol 28: 358–375. 155. Gao H, Toro TB, Paschini M, Braunstein-Ballew B, Cervantes RB, et al. (2010) Telomerase Recruitment in Saccharomyces cerevisiae Is Not Dependent on Tel1-Mediated Phosphorylation of Cdc13. Genetics 186: 1147–1159. 156. Moser BA, Chang Y-T, Kosti J, Nakamura TM (2011) Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast. Nat Struct Mol Biol 18: 1408–1413. 157. Yamazaki H, Tarumoto Y, Ishikawa F (2012) Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev 26: 241–246. 158. Ritchie KB, Mallory JC, Petes TD (1999) Interactions of TLC1 (Which Encodes the RNA Subunit of Telomerase), TEL1, and MEC1 in Regulating 111
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UNIVERSITÀ DEGLI STUDI DI MILANO-B
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Contents
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Abstract
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Riassunto
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Introduction
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Introduction In Saccharomyces cerev
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Introduction Figure 3: A: Diagram s
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Introduction The Replication Protei
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Introduction Rap1 C terminal is ess
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Introduction and highest at G1 phas
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Introduction cleaves the RNA strand
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Introduction In the G1 cell cycle p
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Introduction impaired, and nuclease
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Introduction functionally compromis
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Introduction increasing the interac
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Introduction Similarly in fission y
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Introduction constitutive phosphory
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Shelterin-Like Proteins and Yku Inh
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Bonetti et. al., PLoS Genet. 2010 M
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Rif1 Supports the Function of the C
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Anbalagan et. al., PLoS Genet. 2011
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Anbalagan et. al., PLoS Genet. 2011
Page 71 and 72: Anbalagan et. al., PLoS Genet. 2011
Page 95 and 96: References Anbalagan et. al., PLoS
Page 99: Anbalagan et. al., PLoS Genet. 2011
Page 102 and 103: Discussion The DNA damage proteins
Page 104 and 105: Discussion An hypothesis for the sp
Page 106 and 107: Discussion Figure 14: Model, part 2
Page 108 and 109: Telomeric G4 Discussion Apart from
Page 110 and 111: References 1. Hayflick L (1965) The
Page 112 and 113: References that is required for tel
Page 114 and 115: References 51. Surovtseva YV, Churi
Page 116 and 117: References telomere elongation in S
Page 118 and 119: References 100. Walker JR, Corpina
Page 120 and 121: References 124. Gravel S, Larrivée
Page 124 and 125: References 170. Boltz KA, Leehy K,
Page 126 and 127: References 194. Nimonkar AV, Ozsoy
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