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PHARMACOKINETIC INTERACTION BETWEEN IVABRADINE AND CIPROFLOXACINE …
Concentration (ng/ml)
14
12
10
8
6
4
2
0
Figure 2. Mean (±SD) plasma levels of ivabradine (5 mg p.o.) given alone
(continuous line) or in combination with ciprofloxacin (500 mg, p.o.)
after treatment with ciprofloxacin for 6 days (500 mg p.o.) (dotted line),
n=18; in insert: semilogaritmic presentation.
Table1. Pharmacokinetic parameters of ivabradine administered alone or
after treatment with ciprofloxacin and the result of statistical t test
used for comparison
Pharmacokinetic Ivabradine alone Ivabradine +
p* value,
parameter (±SD)
ciprofloxacin t-test
Cmax (ng/ml) 8.52(4.37) 8.40(4.67) 0.78
tmax (hr) 0.86(0.41) 1.52(0.52) * 0.0014
AUC0-∞ (ng.hr/ml) 27.92(13.59) 28.15(13.74) 0.85
kel (1/hr) 0.35(0.10) 0.37(0.08) 0.36
ka (1/hr) 10.8(6.8) 5.27(6.71) * 0.025
t½ (hr) 2.10(0.60) 1.93(0.44) 0.28
* significance for p