nr. 477 - 2011 - Institut for Natur, Systemer og Modeller (NSM)

116 Expanding and Modifying the DuCa model
the healthy β-cells adding the replication-term shifts the number of days that transpire
before we reach a B-concentration that is associated with overt T1D. Furthermore figure
11.5 shows that after the apoptotic wave has taken its toll, there is a brief increase in
β-cell mass, before the concentration starts to diminish again. It is this difference
between Model B and C that yields the different number of days that pass before
diabetic conditions are reached. (If we imagine cutting out the part of the B-curve
from where it starts to increase to after it has peaked and move the right-most part of
the curve to the left, we get a sense of the influence of the effect of the short period of
growth.)
Based on the models presented in this chapter we will proceed to our final discussion
– this is why we have not treated Model C as thoroughly as the other models in this
chapter. The discussion will provide a brief summary of what we have discovered in
this chapter, a comparison of Model B and C and a discussion of how well Model C fits
our criteria, our (limited) data, and the guidelines provided in chapter 4.