Muscarinic M1, M3, Nicotinic,GABAA and GABAB Receptor ...

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REAL TIME-PCR ANALYSIS Real Time-PCR analysis of AChE Gene expression of AChE mRNA showed significant up regulation (p
Real Time-PCR analysis of α7 nAChR 82 Results α7 nAChR mRNA showed significant up regulation (p
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MUSCARINIC M1, M3, NICOTINIC, GABAA
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ACKNOWLEDGEMENT To the Almighty God
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Seema Chandran, Ms. Neema Ani Manga
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ABBREVIATIONS 5-HIAA 5 Hydroxy indo
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PFC Prefrontal cortex PLC Phospholi
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GABAC Receptors 34 Glutamic Acid De
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Behavioural response of control and
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the cerebral cortex of control and
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Muscarinic M1 receptor analysis Sca
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REAL TIME-PCR ANALYSIS 81 Real Time
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Real Time PCR analysis of GABAAα1
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pancreas of control and experimenta
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utilization is decreased in the bra
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impairment, coma or seizure (Cryer,
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achieving optimal blood sugar contr
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OBJECTIVES OF THE PRESENT STUDY 1.
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Literature Review Diabetes mellitus
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12 Literature Review from the adren
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14 Literature Review Hypoglycemic c
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16 Literature Review respectively)
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18 Literature Review in extracellul
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20 Literature Review substrates in
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22 Literature Review nucleus, altho
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24 Literature Review al., 1990; Lev
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26 Literature Review muscarinic M2
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Signal transduction by muscarinic a
Page 55 and 56: 30 Literature Review nicotinic acet
Page 57 and 58: GABAA Receptors 32 Literature Revie
Page 59 and 60: 34 Literature Review GABAB-mediated
Page 61 and 62: 36 Literature Review (Erlander et a
Page 63 and 64: 38 Literature Review which could be
Page 65 and 66: 40 Literature Review administration
Page 67 and 68: 42 Literature Review the hippocampu
Page 69 and 70: 44 Literature Review understanding
Page 71 and 72: Confocal Dyes Rat primary antibody
Page 73 and 74: antipyryl)-p-benzo quinoneimine. Th
Page 75 and 76: was analyzed. Data was expressed as
Page 77 and 78: ANALYSIS OF THE RECEPTOR BINDING DA
Page 79 and 80: Taqman probes of muscarinic M1, M3,
Page 81 and 82: Taylor, 1968). The islets were isol
Page 83 and 84: Results BODY WEIGHT AND BLOOD GLUCO
Page 85 and 86: 60 Results IIH and C + IIH rats sho
Page 87 and 88: Real Time-PCR analysis of muscarini
Page 89 and 90: Real Time PCR analysis of SOD 64 Re
Page 91 and 92: 66 Results GABAAα1 receptor antibo
Page 93 and 94: 68 Results compared to diabetic gro
Page 95 and 96: 70 Results compared to diabetic rat
Page 97 and 98: 72 Results Muscarinic M3 receptor a
Page 99 and 100: Muscarinic M3 receptor analysis 74
Page 101 and 102: 76 Results group, α7 nAChR mRNA si
Page 103 and 104: 78 Results diabetic rats. In C + II
Page 105: Muscarinic M1 receptor analysis 80
Page 109 and 110: Real Time PCR analysis of phospholi
Page 111 and 112: HIPPOCAMPUS Total muscarinic recept
Page 113 and 114: 88 Results IIH and C + IIH group sh
Page 115 and 116: 90 Results group, GLUT3 mRNA signif
Page 117 and 118: 92 Results α7 nACh receptor antibo
Page 119 and 120: GABA receptor analysis 94 Results S
Page 121 and 122: 96 Results control. D + IIH and C +
Page 123 and 124: Discussion Glucose is the principal
Page 125 and 126: 100 Discussion The ability to sense
Page 127 and 128: 102 Discussion The Y-maze test is a
Page 129 and 130: 104 Discussion CHOLINERGIC ENZYME A
Page 131 and 132: 106 Discussion Pancreas Insulin sec
Page 133 and 134: 108 Discussion 2003). Cholinergic m
Page 135 and 136: 110 Discussion brain for learning,
Page 137 and 138: 112 Discussion hypoglycemia on brai
Page 139 and 140: 114 Discussion shows impaired expre
Page 141 and 142: 116 Discussion glycemic control is
Page 143 and 144: 118 Discussion release (Ilcol et al
Page 145 and 146: 120 Discussion al., 1992), it has t
Page 147 and 148: 122 Discussion metabolic cycles are
Page 149 and 150: 124 Discussion al., 1988). Low bloo
Page 151 and 152: 126 Discussion modulate the second
Page 153 and 154: 128 Discussion between excitation a
Page 155 and 156: 130 Discussion hypoglycemic seizure
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132 Discussion Insulin secretion fr
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134 Discussion hyper and hypoglycem
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136 Discussion receptors in glucose
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138 Discussion exacerbated by recur
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140 Discussion Haces et al., 2010).
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142 Discussion hypoglycemic and dia
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144 Discussion transcription factor
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Summary 1. Insulin induced hypoglyc
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148 Summary specific antibodies con
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150 Summary 16. Transcription facto
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References Abdelmalik PA, Shannon P
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Akwa Y, Ladurelle N, Covey F, Bauli
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Arison RN, Ciaccio EI, Glitzer MS,
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Balters E, Francesco M. (2002). New
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Brezenoff HE, Xiao YF. (1986). Acet
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Caulfield MP, Birdsall NJM. (1998).
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Cherubini E, Martina M, Sciancalepo
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Cryer PE. (2002b). The pathophysiol
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Delgado Esteban M, Almeida A, Bolan
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Dutar P, Nicoll RA. (1989). Pharmac
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Golding DW, Pow DV. (1990). Neurose
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Haddad GG, Jiang C. (1993). Mechani
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Johnson E, Deckwerth T. (1993). Mol
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Kelley GG, Zawalich KC, Zawalich WS
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Quan L, Meili G, Chang BS, Lowenste
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Robinson R, Krishnakumar A, Paulose
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Salkovic M, Lackovic Z. (1992). Bra
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Scheucher A. Alvarez AL, Torres N,
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(2002). Sulfonylurea receptor type
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Steriade M. (1996). Arousal: revisi
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Takayama C, Inoue Y. (2003). Normal
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Unger J, McNeill TH, Moxley RT 3rd,
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pentabromodiphenyl ether (PBDE 99).
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Weiner DM, Levey AI, Brann MR. (199
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Wredling R, Levander S, Adamson U,
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Zhao W, Chen H, Xu H, Moore E, Meir
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6. Anju T R, Pretty Mary Abraham, S
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Body weight (gm) 300 250 200 150 10
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Figure-3 Blood glucose levels at di
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Figure-5 Behavioural response of co
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Figure-7 Scatchard analysis of [ 3
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Figure-11 Real Time PCR amplificati
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C D + IIH Figure--25 Muscarinic M1
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Figure--27 α 7 nACh receptor expre
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Figure--47 Muscarinic M1 receptor e
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Figure--49 α7 nicotinic acetylchol
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Figure--71 α7 nicotinic acetylchol
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C Figure--93 GABAAα1 receptor expr
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Figure-101 Real Time PCR amplificat
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Figure—113 Muscarinic M3 receptor
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Figure--115 GABAAα1 receptor expre
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Figure-117 Scatchard analysis of [
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Figure-119 Scatchard analysis of [
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Figure-131 Muscarinic M1 receptor e
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C D + IIH Figure-133 GABAAα1 recep
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