Muscarinic M1, M3, Nicotinic,GABAA and GABAB Receptor ...

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Olson AL, Pessin JE. (1996). Structure, function, and regulation of the mammalian facilitative glucose transporter gene family. Annu. Rev. Nutr, 16: 235–256. Olsen WR, Avoli M. (1997). GABA and epileptogenesis. Epilepsia, 38: 399–407. Ouyang C, Guo L, Lu Q, Xu X, Wang H. (2007). Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum. Neurosci Lett, 420: 174–178. Owen C, Wanling Z, Yuyan D, Rory JM, Robert SS. (2006). Blockade of GABAA Receptors in the Ventromedial Hypothalamus Further Stimulates Glucagon and Sympathoadrenal but Not the Hypothalamo–Pituitary–Adrenal Response to Hypoglycaemia. Diabetes, 55: 1080–1087. Padayatti PS, Paulose CS. (1999). Alpha2 adrenergic and high affinity serotonergic receptor changes in the brain stem of streptozotocin–induced diabetic rats. Life Sci, 65: 403–414. Paik SG, Fleischer N, Shin SI. (1980). Insulin–dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: obligatory role of cell –mediated autoimmune processes. Proc. Natl. Acad. Sci, 77: 6129–6133. Palovcik RA, Phillips MI, Kappy MS, Raizada MK. (1984). Insulin inhibits pyramidal neurons in hippocampal slices. Brain Res, 309: 187–191. Pang KC, Nocera R, Secor AJ, Yoder RM. (2001). GABAergic septohippocampal neurons are not necessary for spatial memory. Hippocampus, 11: 814–827.
Paramo B, Hernández–Fonseca K, Estrada–Sánchez AM, Jiménez N, Hernández– Cruz A, Massieu L. (2010). Pathways involved in the generation of reactive oxygen and nitrogen species during glucose deprivation and its role on the death of cultured hippocampal neurons. Neuroscience, 167: 1057–1069. Paramore DS, Fanelli CG, Shah SD, Cryer PE. (1998). Forearm norepinephrine spillover during standing, hyperinsulinemia, and hypoglycemia. Am J Physiol, 275: E872–E881. Pardridge WM, Triguero D, Farrell CR. (1990). Down–regulation of blood brain barrier glucose transporter in experimental diabetes. Diabetes, 39: 1040–1044. Pardridge WM. (1983). Brain metabolism: a perspective from the blood–brain barrier. Physiol. Rev, 63: 1481–1535. Pare D, Steriade M. (1993). The reticular thalamic nucleus projects to the contralateral dorsal thalamus in macaque monkey. Neurosci Lett, 154: 96–100. Park CR, Seeley RJ, Craft S, Woods SC. (2000). Intracerebroventricular insulin enhances memory in a passive–avoidance task. Physiol Behav, 68: 509–514. Park CR. (2001). Cognitive effects of insulin in the central nervous system. Neurosci. Biobehav. Rev, 25: 311–323. Parvizi J, Damasio AR. (2003). Neuroanatomical correlates of brainstem coma. Brain, 126: 1524–1536.
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MUSCARINIC M1, M3, NICOTINIC, GABAA
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ACKNOWLEDGEMENT To the Almighty God
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Seema Chandran, Ms. Neema Ani Manga
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ABBREVIATIONS 5-HIAA 5 Hydroxy indo
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PFC Prefrontal cortex PLC Phospholi
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GABAC Receptors 34 Glutamic Acid De
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Behavioural response of control and
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the cerebral cortex of control and
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Muscarinic M1 receptor analysis Sca
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REAL TIME-PCR ANALYSIS 81 Real Time
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Real Time PCR analysis of GABAAα1
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pancreas of control and experimenta
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utilization is decreased in the bra
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impairment, coma or seizure (Cryer,
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achieving optimal blood sugar contr
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OBJECTIVES OF THE PRESENT STUDY 1.
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Literature Review Diabetes mellitus
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12 Literature Review from the adren
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14 Literature Review Hypoglycemic c
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16 Literature Review respectively)
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18 Literature Review in extracellul
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20 Literature Review substrates in
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22 Literature Review nucleus, altho
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24 Literature Review al., 1990; Lev
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26 Literature Review muscarinic M2
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Signal transduction by muscarinic a
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30 Literature Review nicotinic acet
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GABAA Receptors 32 Literature Revie
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34 Literature Review GABAB-mediated
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36 Literature Review (Erlander et a
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38 Literature Review which could be
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40 Literature Review administration
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42 Literature Review the hippocampu
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44 Literature Review understanding
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Confocal Dyes Rat primary antibody
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antipyryl)-p-benzo quinoneimine. Th
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was analyzed. Data was expressed as
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ANALYSIS OF THE RECEPTOR BINDING DA
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Taqman probes of muscarinic M1, M3,
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Taylor, 1968). The islets were isol
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Results BODY WEIGHT AND BLOOD GLUCO
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60 Results IIH and C + IIH rats sho
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Real Time-PCR analysis of muscarini
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Real Time PCR analysis of SOD 64 Re
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66 Results GABAAα1 receptor antibo
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68 Results compared to diabetic gro
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70 Results compared to diabetic rat
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72 Results Muscarinic M3 receptor a
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Muscarinic M3 receptor analysis 74
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76 Results group, α7 nAChR mRNA si
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78 Results diabetic rats. In C + II
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Muscarinic M1 receptor analysis 80
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Real Time-PCR analysis of α7 nAChR
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Real Time PCR analysis of phospholi
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HIPPOCAMPUS Total muscarinic recept
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88 Results IIH and C + IIH group sh
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90 Results group, GLUT3 mRNA signif
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92 Results α7 nACh receptor antibo
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GABA receptor analysis 94 Results S
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96 Results control. D + IIH and C +
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Discussion Glucose is the principal
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100 Discussion The ability to sense
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102 Discussion The Y-maze test is a
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104 Discussion CHOLINERGIC ENZYME A
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106 Discussion Pancreas Insulin sec
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108 Discussion 2003). Cholinergic m
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110 Discussion brain for learning,
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112 Discussion hypoglycemia on brai
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114 Discussion shows impaired expre
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116 Discussion glycemic control is
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118 Discussion release (Ilcol et al
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120 Discussion al., 1992), it has t
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122 Discussion metabolic cycles are
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124 Discussion al., 1988). Low bloo
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126 Discussion modulate the second
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128 Discussion between excitation a
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130 Discussion hypoglycemic seizure
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132 Discussion Insulin secretion fr
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134 Discussion hyper and hypoglycem
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136 Discussion receptors in glucose
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138 Discussion exacerbated by recur
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140 Discussion Haces et al., 2010).
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142 Discussion hypoglycemic and dia
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144 Discussion transcription factor
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Summary 1. Insulin induced hypoglyc
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148 Summary specific antibodies con
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150 Summary 16. Transcription facto
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References Abdelmalik PA, Shannon P
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Akwa Y, Ladurelle N, Covey F, Bauli
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Arison RN, Ciaccio EI, Glitzer MS,
Page 183 and 184: Balters E, Francesco M. (2002). New
Page 185 and 186: Bettler B, Kaupmann K, Mosbacher J,
Page 187 and 188: Boess FG, De Vry J, Erb C, Flessner
Page 189 and 190: Brezenoff HE, Xiao YF. (1986). Acet
Page 191 and 192: Caulfield MP, Birdsall NJM. (1998).
Page 193 and 194: Cherubini E, Martina M, Sciancalepo
Page 195 and 196: Cryer PE. (2002b). The pathophysiol
Page 197 and 198: Delgado Esteban M, Almeida A, Bolan
Page 199 and 200: Dutar P, Nicoll RA. (1989). Pharmac
Page 201 and 202: Exton JH, Jefferson LS, Butcher RW,
Page 203 and 204: Frier B. (2000). Hypoglycaemia—cl
Page 205 and 206: Gerich JE, Schneider V, Dippe SE, L
Page 207 and 208: Golding DW, Pow DV. (1990). Neurose
Page 209 and 210: Haddad GG, Jiang C. (1993). Mechani
Page 211 and 212: Havel PnJ, Dunning BnE, Verchere Cn
Page 213 and 214: Hsu KS, Huang CC, Gean PW. (1995).
Page 215 and 216: Johnson E, Deckwerth T. (1993). Mol
Page 217 and 218: Kanjhan R, Housley GD, Burton LD, C
Page 219 and 220: Kelley GG, Zawalich KC, Zawalich WS
Page 221 and 222: Krnjevic K. (1993). Central choline
Page 223 and 224: Lackovic Z, Salkovic M, Kuci Z, Rel
Page 225 and 226: Lipton P. (1999). Ischemic cell dea
Page 227 and 228: Mares P, Kubova H, Zouhar A, Folber
Page 229 and 230: McCulloch DK, Raghu PK, Koerker DJ,
Page 231 and 232: Miyakawa T, Yamada M, Duttaroy A, W
Page 233: Nusser Z, Sieghart W, Somogyi P. (1
Page 237 and 238: Peeyush KT, Savitha B, Sherin A, An
Page 239 and 240: Quan L, Meili G, Chang BS, Lowenste
Page 241 and 242: Robinson R, Krishnakumar A, Paulose
Page 243 and 244: Salkovic M, Lackovic Z. (1992). Bra
Page 245 and 246: Scheucher A. Alvarez AL, Torres N,
Page 247 and 248: (2002). Sulfonylurea receptor type
Page 249 and 250: Steriade M. (1996). Arousal: revisi
Page 251 and 252: Takayama C, Inoue Y. (2003). Normal
Page 253 and 254: Unger J, McNeill TH, Moxley RT 3rd,
Page 255 and 256: pentabromodiphenyl ether (PBDE 99).
Page 257 and 258: Weiner DM, Levey AI, Brann MR. (199
Page 259 and 260: Wredling R, Levander S, Adamson U,
Page 261 and 262: Zhao W, Chen H, Xu H, Moore E, Meir
Page 263 and 264: 6. Anju T R, Pretty Mary Abraham, S
Page 265 and 266: Body weight (gm) 300 250 200 150 10
Page 267 and 268: Figure-3 Blood glucose levels at di
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Figure-21 Real Time PCR amplificati
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C D + IIH Figure--25 Muscarinic M1
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Figure--27 α 7 nACh receptor expre
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Figure-29 Scatchard analysis of [ 3
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Figure--47 Muscarinic M1 receptor e
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Figure--49 α7 nicotinic acetylchol
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Figure--71 α7 nicotinic acetylchol
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C Figure--93 GABAAα1 receptor expr
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Figure-101 Real Time PCR amplificat
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Figure—113 Muscarinic M3 receptor
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Figure--115 GABAAα1 receptor expre
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Figure-117 Scatchard analysis of [
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Figure-119 Scatchard analysis of [
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Figure-131 Muscarinic M1 receptor e
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C D + IIH Figure-133 GABAAα1 recep
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