Muscarinic M1, M3, Nicotinic,GABAA and GABAB Receptor ...

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Real Time-PCR analysis of α7 nAChR 69 Real Time PCR analysis of GAD 69 Real Time PCR analysis of GABAAα1 receptor 69 Real Time PCR analysis of GABAB receptor 69 Real Time PCR analysis of GLUT3 70 Real Time PCR analysis of insulin receptor 70 Real Time PCR analysis of SOD 70 Real Time PCR analysis of Bax 70 Real Time PCR analysis of phospholipase C 71 Real Time PCR analysis of CREB 71 CONFOCAL STUDIES 71 Muscarinic M1 receptor antibody staining in the cerebellum of control and experimental rat 71 Muscarinic M3 receptor antibody staining in the cerebellum of control and experimental rats 72 α7 nACh receptor antibody staining in the cerebellum of control and experimental rats 72 GABAAα1 receptor antibody staining in the cerebellum of control and experimental rats 72 BRAIN STEM 73 Total muscarinic receptor analysis Scatchard analysis of [ 3 H] QNB binding against total muscarinic receptor antagonist, atropine in the brain stem of control and experimental rats 73
Muscarinic M1 receptor analysis Scatchard analysis of [ 3 H] QNB binding against muscarinic M1 receptor antagonist, pirenzepine in the brain stem of control and experimental rats. 73 Muscarinic M3 receptor analysis Scatchard analysis of [ 3 H] DAMP binding against muscarinic M3 receptor, antagonist, 4-DAMP mustard in the brain stem of control and experimental rats. 74 GABA receptor analysis Scatchard analysis of [ 3 H] GABA binding against GABA in the brain stem of control and experimental rats 74 REAL TIME-PCR ANALYSIS 74 Real Time-PCR analysis of AChE 74 Real Time-PCR analysis of ChAT 75 Real Time-PCR analysis of muscarinic M1 receptor 75 Real Time-PCR analysis of muscarinic M3 receptor 75 Real Time-PCR analysis of α7 nAChR 75 Real Time PCR analysis of GAD 76 Real Time PCR analysis of GABAAα1 receptor 76 Real Time PCR analysis of GABAB receptor 76 Real Time PCR analysis of GLUT3 76 Real Time PCR analysis of insulin receptor 77 Real Time PCR analysis of superoxide dismutase (SOD) 77 Real Time PCR analysis of Bax 77 Real Time PCR analysis of phospholipase C 77 Real Time PCR analysis of CREB 78
Page 2: MUSCARINIC M1, M3, NICOTINIC, GABAA
Page 5 and 6: ACKNOWLEDGEMENT To the Almighty God
Page 7 and 8: Seema Chandran, Ms. Neema Ani Manga
Page 9 and 10: ABBREVIATIONS 5-HIAA 5 Hydroxy indo
Page 11 and 12: PFC Prefrontal cortex PLC Phospholi
Page 13 and 14: GABAC Receptors 34 Glutamic Acid De
Page 15 and 16: Behavioural response of control and
Page 17: the cerebral cortex of control and
Page 21 and 22: REAL TIME-PCR ANALYSIS 81 Real Time
Page 23 and 24: Real Time PCR analysis of GABAAα1
Page 25 and 26: pancreas of control and experimenta
Page 27 and 28: utilization is decreased in the bra
Page 29 and 30: impairment, coma or seizure (Cryer,
Page 31 and 32: achieving optimal blood sugar contr
Page 33 and 34: OBJECTIVES OF THE PRESENT STUDY 1.
Page 35 and 36: Literature Review Diabetes mellitus
Page 37 and 38: 12 Literature Review from the adren
Page 39 and 40: 14 Literature Review Hypoglycemic c
Page 41 and 42: 16 Literature Review respectively)
Page 43 and 44: 18 Literature Review in extracellul
Page 45 and 46: 20 Literature Review substrates in
Page 47 and 48: 22 Literature Review nucleus, altho
Page 49 and 50: 24 Literature Review al., 1990; Lev
Page 51 and 52: 26 Literature Review muscarinic M2
Page 53 and 54: Signal transduction by muscarinic a
Page 55 and 56: 30 Literature Review nicotinic acet
Page 57 and 58: GABAA Receptors 32 Literature Revie
Page 59 and 60: 34 Literature Review GABAB-mediated
Page 61 and 62: 36 Literature Review (Erlander et a
Page 63 and 64: 38 Literature Review which could be
Page 65 and 66: 40 Literature Review administration
Page 67 and 68: 42 Literature Review the hippocampu
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44 Literature Review understanding
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Confocal Dyes Rat primary antibody
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antipyryl)-p-benzo quinoneimine. Th
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was analyzed. Data was expressed as
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ANALYSIS OF THE RECEPTOR BINDING DA
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Taqman probes of muscarinic M1, M3,
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Taylor, 1968). The islets were isol
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Results BODY WEIGHT AND BLOOD GLUCO
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60 Results IIH and C + IIH rats sho
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Real Time-PCR analysis of muscarini
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Real Time PCR analysis of SOD 64 Re
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66 Results GABAAα1 receptor antibo
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68 Results compared to diabetic gro
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70 Results compared to diabetic rat
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72 Results Muscarinic M3 receptor a
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Muscarinic M3 receptor analysis 74
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76 Results group, α7 nAChR mRNA si
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78 Results diabetic rats. In C + II
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Muscarinic M1 receptor analysis 80
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Real Time-PCR analysis of α7 nAChR
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Real Time PCR analysis of phospholi
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HIPPOCAMPUS Total muscarinic recept
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88 Results IIH and C + IIH group sh
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90 Results group, GLUT3 mRNA signif
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92 Results α7 nACh receptor antibo
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GABA receptor analysis 94 Results S
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96 Results control. D + IIH and C +
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Discussion Glucose is the principal
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100 Discussion The ability to sense
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102 Discussion The Y-maze test is a
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104 Discussion CHOLINERGIC ENZYME A
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106 Discussion Pancreas Insulin sec
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108 Discussion 2003). Cholinergic m
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110 Discussion brain for learning,
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112 Discussion hypoglycemia on brai
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114 Discussion shows impaired expre
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116 Discussion glycemic control is
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118 Discussion release (Ilcol et al
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120 Discussion al., 1992), it has t
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122 Discussion metabolic cycles are
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124 Discussion al., 1988). Low bloo
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126 Discussion modulate the second
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128 Discussion between excitation a
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130 Discussion hypoglycemic seizure
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132 Discussion Insulin secretion fr
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134 Discussion hyper and hypoglycem
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136 Discussion receptors in glucose
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138 Discussion exacerbated by recur
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140 Discussion Haces et al., 2010).
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142 Discussion hypoglycemic and dia
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144 Discussion transcription factor
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Summary 1. Insulin induced hypoglyc
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148 Summary specific antibodies con
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150 Summary 16. Transcription facto
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References Abdelmalik PA, Shannon P
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Body weight (gm) 300 250 200 150 10
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Figure-3 Blood glucose levels at di
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Figure-5 Behavioural response of co
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Figure-7 Scatchard analysis of [ 3
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Figure-11 Real Time PCR amplificati
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C D + IIH Figure--25 Muscarinic M1
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Figure--27 α 7 nACh receptor expre
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Figure--47 Muscarinic M1 receptor e
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Figure--49 α7 nicotinic acetylchol
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Figure--71 α7 nicotinic acetylchol
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C Figure--93 GABAAα1 receptor expr
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Figure-101 Real Time PCR amplificat
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Figure—113 Muscarinic M3 receptor
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Figure--115 GABAAα1 receptor expre
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Figure-117 Scatchard analysis of [
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Figure-119 Scatchard analysis of [
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Figure-131 Muscarinic M1 receptor e
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C D + IIH Figure-133 GABAAα1 recep
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