Muscarinic M1, M3, Nicotinic,GABAA and GABAB Receptor ...

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Tkacs NC, Pan Y, Raghupathi R, Dunn–Meynell AA, Levin BE. (2005). Cortical Fluoro–Jade staining and blunted adrenomedullary response to hypoglycemia after noncoma hypoglycemia in rats. J Cereb Blood Flow Metab, 25: 1645–1655. Torrao AS, Lindstrom JM, Britto LR. (2003). Nicotine and alpha–bungarotoxin modify the dendritic growth of cholinoceptive neurons in the developing chick tectum. Dev Brain Res, 143: 115–118. Treiman DM. (2001). GABAergic mechanisms in epilepsy. Epilepsia, 42: 8–12. Tzavara ET, Bymaster FP, Felder CC, Wade M, Gomeza J, Wess J, McKinzie DL, Nomikos GG. (2003). Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4, and M2/M4 muscarinic receptor knockout mice. Mol Psychiatry, 8: 673–679. Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, Kulkarni RN. (2006). Total insulin and IGF–I resistance in pancreatic beta cells causes overt diabetes. Nat Genet, 38: 583–588. Uemura E, Greenlee HW. (2001). Amyloid beta–peptide inhibits neuronal glucose uptake by preventing exocytosis. Exp Neurol, 170: 270–276. Uemura E, Greenlee HW. (2006). Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3. Experimental Neurology, 198: 48–53.
Unger J, McNeill TH, Moxley RT 3rd, White M, Moss A, Livingston JN. (1989). Distribution of insulin receptor–like immunoreactivity in the rat forebrain. Neuroscience, 31: 143–157. Unger JW, Livingston JN, Moss AM. (1991). Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects. Prog Neurobiol, 36: 343–362. Unger RH, Orci L. (1975). The essential role of glucagon in the pathogenesis of diabetes mellitus. Lancet, 1: 14–16. Unger RH, Orci L. (1977). Possible roles of the pancreatic D–cell in the normal and diabetic states. Diabetes, 26: 241–244. Valentin A, Pavlov, Mahendar O, Margot Gallowitsch–Puerta, Kanta O, Jared M, Huston, Christopher J, Czura, Yousef Al–Abed, Kevin J. (2006). Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia. Proc Natl Acad Sci, 103: 5219–5223. Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ. (2005). Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology, 64: 1348–1353. Van der Zee EA, Buwalda B, Strubbe JH, Strosberg AD, Luiten PG. (1992). Immunocytochemical localization of muscarinic acetylcholine receptors in the rat endocrine pancreas. Cell Tissue Res, 269: 99–106. Van Der Zee EA, Luiten GM. (1999). Muscarinic acetylcholine receptors in the Hippocampus, neocortex and amygdala: a Review of immunocytochemical
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MUSCARINIC M1, M3, NICOTINIC, GABAA
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ACKNOWLEDGEMENT To the Almighty God
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Seema Chandran, Ms. Neema Ani Manga
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ABBREVIATIONS 5-HIAA 5 Hydroxy indo
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PFC Prefrontal cortex PLC Phospholi
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GABAC Receptors 34 Glutamic Acid De
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Behavioural response of control and
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the cerebral cortex of control and
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Muscarinic M1 receptor analysis Sca
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REAL TIME-PCR ANALYSIS 81 Real Time
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Real Time PCR analysis of GABAAα1
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pancreas of control and experimenta
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utilization is decreased in the bra
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impairment, coma or seizure (Cryer,
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achieving optimal blood sugar contr
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OBJECTIVES OF THE PRESENT STUDY 1.
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Literature Review Diabetes mellitus
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12 Literature Review from the adren
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14 Literature Review Hypoglycemic c
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16 Literature Review respectively)
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18 Literature Review in extracellul
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20 Literature Review substrates in
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22 Literature Review nucleus, altho
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24 Literature Review al., 1990; Lev
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26 Literature Review muscarinic M2
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Signal transduction by muscarinic a
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30 Literature Review nicotinic acet
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GABAA Receptors 32 Literature Revie
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34 Literature Review GABAB-mediated
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36 Literature Review (Erlander et a
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38 Literature Review which could be
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40 Literature Review administration
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42 Literature Review the hippocampu
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44 Literature Review understanding
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Confocal Dyes Rat primary antibody
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antipyryl)-p-benzo quinoneimine. Th
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was analyzed. Data was expressed as
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ANALYSIS OF THE RECEPTOR BINDING DA
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Taqman probes of muscarinic M1, M3,
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Taylor, 1968). The islets were isol
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Results BODY WEIGHT AND BLOOD GLUCO
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60 Results IIH and C + IIH rats sho
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Real Time-PCR analysis of muscarini
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Real Time PCR analysis of SOD 64 Re
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66 Results GABAAα1 receptor antibo
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68 Results compared to diabetic gro
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70 Results compared to diabetic rat
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72 Results Muscarinic M3 receptor a
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Muscarinic M3 receptor analysis 74
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76 Results group, α7 nAChR mRNA si
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78 Results diabetic rats. In C + II
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Muscarinic M1 receptor analysis 80
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Real Time-PCR analysis of α7 nAChR
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Real Time PCR analysis of phospholi
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HIPPOCAMPUS Total muscarinic recept
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88 Results IIH and C + IIH group sh
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90 Results group, GLUT3 mRNA signif
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92 Results α7 nACh receptor antibo
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GABA receptor analysis 94 Results S
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96 Results control. D + IIH and C +
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Discussion Glucose is the principal
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100 Discussion The ability to sense
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102 Discussion The Y-maze test is a
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104 Discussion CHOLINERGIC ENZYME A
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106 Discussion Pancreas Insulin sec
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108 Discussion 2003). Cholinergic m
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110 Discussion brain for learning,
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112 Discussion hypoglycemia on brai
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114 Discussion shows impaired expre
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116 Discussion glycemic control is
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118 Discussion release (Ilcol et al
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120 Discussion al., 1992), it has t
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122 Discussion metabolic cycles are
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124 Discussion al., 1988). Low bloo
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126 Discussion modulate the second
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128 Discussion between excitation a
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130 Discussion hypoglycemic seizure
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132 Discussion Insulin secretion fr
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134 Discussion hyper and hypoglycem
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136 Discussion receptors in glucose
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138 Discussion exacerbated by recur
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140 Discussion Haces et al., 2010).
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142 Discussion hypoglycemic and dia
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144 Discussion transcription factor
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Summary 1. Insulin induced hypoglyc
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148 Summary specific antibodies con
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150 Summary 16. Transcription facto
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References Abdelmalik PA, Shannon P
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Akwa Y, Ladurelle N, Covey F, Bauli
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Arison RN, Ciaccio EI, Glitzer MS,
Page 183 and 184:
Balters E, Francesco M. (2002). New
Page 185 and 186:
Bettler B, Kaupmann K, Mosbacher J,
Page 187 and 188:
Boess FG, De Vry J, Erb C, Flessner
Page 189 and 190:
Brezenoff HE, Xiao YF. (1986). Acet
Page 191 and 192:
Caulfield MP, Birdsall NJM. (1998).
Page 193 and 194:
Cherubini E, Martina M, Sciancalepo
Page 195 and 196:
Cryer PE. (2002b). The pathophysiol
Page 197 and 198:
Delgado Esteban M, Almeida A, Bolan
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Dutar P, Nicoll RA. (1989). Pharmac
Page 201 and 202: Exton JH, Jefferson LS, Butcher RW,
Page 203 and 204: Frier B. (2000). Hypoglycaemia—cl
Page 205 and 206: Gerich JE, Schneider V, Dippe SE, L
Page 207 and 208: Golding DW, Pow DV. (1990). Neurose
Page 209 and 210: Haddad GG, Jiang C. (1993). Mechani
Page 211 and 212: Havel PnJ, Dunning BnE, Verchere Cn
Page 213 and 214: Hsu KS, Huang CC, Gean PW. (1995).
Page 215 and 216: Johnson E, Deckwerth T. (1993). Mol
Page 217 and 218: Kanjhan R, Housley GD, Burton LD, C
Page 219 and 220: Kelley GG, Zawalich KC, Zawalich WS
Page 221 and 222: Krnjevic K. (1993). Central choline
Page 223 and 224: Lackovic Z, Salkovic M, Kuci Z, Rel
Page 225 and 226: Lipton P. (1999). Ischemic cell dea
Page 227 and 228: Mares P, Kubova H, Zouhar A, Folber
Page 229 and 230: McCulloch DK, Raghu PK, Koerker DJ,
Page 231 and 232: Miyakawa T, Yamada M, Duttaroy A, W
Page 233 and 234: Nusser Z, Sieghart W, Somogyi P. (1
Page 235 and 236: Paramo B, Hernández-Fonseca K, Est
Page 237 and 238: Peeyush KT, Savitha B, Sherin A, An
Page 239 and 240: Quan L, Meili G, Chang BS, Lowenste
Page 241 and 242: Robinson R, Krishnakumar A, Paulose
Page 243 and 244: Salkovic M, Lackovic Z. (1992). Bra
Page 245 and 246: Scheucher A. Alvarez AL, Torres N,
Page 247 and 248: (2002). Sulfonylurea receptor type
Page 249 and 250: Steriade M. (1996). Arousal: revisi
Page 251: Takayama C, Inoue Y. (2003). Normal
Page 255 and 256: pentabromodiphenyl ether (PBDE 99).
Page 257 and 258: Weiner DM, Levey AI, Brann MR. (199
Page 259 and 260: Wredling R, Levander S, Adamson U,
Page 261 and 262: Zhao W, Chen H, Xu H, Moore E, Meir
Page 263 and 264: 6. Anju T R, Pretty Mary Abraham, S
Page 265 and 266: Body weight (gm) 300 250 200 150 10
Page 267 and 268: Figure-3 Blood glucose levels at di
Page 269 and 270: Figure-5 Behavioural response of co
Page 271 and 272: Figure-7 Scatchard analysis of [ 3
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Figure-39 Real Time PCR amplificati
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Figure--47 Muscarinic M1 receptor e
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Figure--49 α7 nicotinic acetylchol
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Figure-51 Scatchard analysis of [ 3
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Figure--71 α7 nicotinic acetylchol
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C Figure--93 GABAAα1 receptor expr
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Figure-101 Real Time PCR amplificat
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Figure—113 Muscarinic M3 receptor
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Figure--115 GABAAα1 receptor expre
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Figure-117 Scatchard analysis of [
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Figure-119 Scatchard analysis of [
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Figure-131 Muscarinic M1 receptor e
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C D + IIH Figure-133 GABAAα1 recep
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