Muscarinic M1, M3, Nicotinic,GABAA and GABAB Receptor ...

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Papers Published 1. Sherin Antony, Peeyush Kumar T, Jobin Mathew, Anju T.R and C. S. Paulose. (2010). Hypoglycemia Induced Changes in Cholinergic receptor expression in the cerebellum of diabetic rats. Journal of Biomedical sciences. Journal of Biomedical Science, 17:7. 2. Anu Joseph, Sherin Antony, C. S. Paulose. (2008). Increased glutamate receptor gene expression in the cerebral cortex of insulin induced hypoglycemic and streptozotocin-induced diabetic rats. Neuroscience, 156: 298-304 3. Savitha, B., Jobin Mathew., Sherin, Antony., and Paulose, C. S. (2009). Muscarinic M1, M3 receptors function in the brainstem of streptozotocin induced diabetic rats: their role in insulin secretion from the pancreatic islets as a function of age. European Journal of Pharmacology, 608: 14-22. 4. Peeyush Kumar T, Savitha Balakrishnan, Sherin Antony, Anju T R, and Jes Paul. 2010. Cholinergic, Dopaminergic and Insulin Receptors Gene Expression in the Cerebellum of Streptozotocin Induced Diabetic Rats: Functional Regulation with Vitamin D3 Supplementation. Pharmacology Biochemistry and behavior. Pharmacology Biochemistry and Behaviour, 95: 216-222. 5. Peeyush Kumar T., Sherin Antony., Nandhu M S, Jayanarayanan S, Naijil George & Paulose C. S. (2010). Vitamin D3 Restores Altered Cholinergic and Insulin Receptor expression in the Cerebral Cortex and Muscarinic M3 receptor expression in Pancreatic Islets of Streptozotocin Induced Diabetic Rats. Journal of Nutritional Biochemistry doi: 01.2045/j.nb.2010.03.0435 (in press).
6. Anju T R, Pretty Mary Abraham, Sherin Antony; Paulose CS. (2010). Alterations in cortical GABA B receptors in neonatal rats exposed to hypoxic stress: Role of glucose, oxygen and epinephrine resuscitation. Molecular and Cellular Biochemistry doi: 10.1007/s11010-010-0491-9 (in press). Abstracts/Presentations 1. Sherin Antony, Anu Joseph, C. S. Paulose. Kinetic parameters of acetylcholine esterase in the heart of Streptozotocin Induced Diabetic and Insulin Induced Hypoglycemic rats. Meeting of Society of Biological Chemists (India) conducted in Sri Venkiteswara University, Thirupathi (2007). 2. Anu Joseph, Sherin Antony, C. S. Paulose. Decreased α-2a adrenergic receptor gene expression in the Hypothalamus and Brainstem of Insulin Induced Hypoglycaemic and Streptozotocin Induced Diabetic Rats. Annual meeting of Society for Biotechnologists, India and National Symposium on Current Trends in Stem Cell Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram (2007). 3. Sherin Antony, Anu Joseph, C. S. Paulose. Decreased [ 3 H] QNB binding to muscarinic M1 receptors in the cerebral cortex of diabetic and insulin induced hypoglycemic rats. 8 th Biennial meeting of Asia Pacific Society for Neurochemistry Symposium organized by International Society for Neurochemistry/Asia Pacific Society for Neurochemistry/International Brain Research Organization held in Shanghai, China (2008). 4. Sherin Antony, Anu Joseph, Peeyush Kumar T, C. S. Paulose. Enhanced Muscarinic M3 receptor gene expression in the cerebral cortex of Diabetic
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MUSCARINIC M1, M3, NICOTINIC, GABAA
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ACKNOWLEDGEMENT To the Almighty God
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Seema Chandran, Ms. Neema Ani Manga
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ABBREVIATIONS 5-HIAA 5 Hydroxy indo
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PFC Prefrontal cortex PLC Phospholi
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GABAC Receptors 34 Glutamic Acid De
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Behavioural response of control and
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the cerebral cortex of control and
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Muscarinic M1 receptor analysis Sca
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REAL TIME-PCR ANALYSIS 81 Real Time
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Real Time PCR analysis of GABAAα1
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pancreas of control and experimenta
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utilization is decreased in the bra
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impairment, coma or seizure (Cryer,
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achieving optimal blood sugar contr
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OBJECTIVES OF THE PRESENT STUDY 1.
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Literature Review Diabetes mellitus
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12 Literature Review from the adren
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14 Literature Review Hypoglycemic c
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16 Literature Review respectively)
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18 Literature Review in extracellul
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20 Literature Review substrates in
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22 Literature Review nucleus, altho
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24 Literature Review al., 1990; Lev
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26 Literature Review muscarinic M2
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Signal transduction by muscarinic a
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30 Literature Review nicotinic acet
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GABAA Receptors 32 Literature Revie
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34 Literature Review GABAB-mediated
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36 Literature Review (Erlander et a
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38 Literature Review which could be
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40 Literature Review administration
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42 Literature Review the hippocampu
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44 Literature Review understanding
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Confocal Dyes Rat primary antibody
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antipyryl)-p-benzo quinoneimine. Th
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was analyzed. Data was expressed as
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ANALYSIS OF THE RECEPTOR BINDING DA
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Taqman probes of muscarinic M1, M3,
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Taylor, 1968). The islets were isol
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Results BODY WEIGHT AND BLOOD GLUCO
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60 Results IIH and C + IIH rats sho
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Real Time-PCR analysis of muscarini
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Real Time PCR analysis of SOD 64 Re
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66 Results GABAAα1 receptor antibo
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68 Results compared to diabetic gro
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70 Results compared to diabetic rat
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72 Results Muscarinic M3 receptor a
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Muscarinic M3 receptor analysis 74
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76 Results group, α7 nAChR mRNA si
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78 Results diabetic rats. In C + II
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Muscarinic M1 receptor analysis 80
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Real Time-PCR analysis of α7 nAChR
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Real Time PCR analysis of phospholi
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HIPPOCAMPUS Total muscarinic recept
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88 Results IIH and C + IIH group sh
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90 Results group, GLUT3 mRNA signif
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92 Results α7 nACh receptor antibo
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GABA receptor analysis 94 Results S
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96 Results control. D + IIH and C +
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Discussion Glucose is the principal
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100 Discussion The ability to sense
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102 Discussion The Y-maze test is a
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104 Discussion CHOLINERGIC ENZYME A
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106 Discussion Pancreas Insulin sec
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108 Discussion 2003). Cholinergic m
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110 Discussion brain for learning,
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112 Discussion hypoglycemia on brai
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114 Discussion shows impaired expre
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116 Discussion glycemic control is
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118 Discussion release (Ilcol et al
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120 Discussion al., 1992), it has t
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122 Discussion metabolic cycles are
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124 Discussion al., 1988). Low bloo
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126 Discussion modulate the second
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128 Discussion between excitation a
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130 Discussion hypoglycemic seizure
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132 Discussion Insulin secretion fr
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134 Discussion hyper and hypoglycem
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136 Discussion receptors in glucose
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138 Discussion exacerbated by recur
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140 Discussion Haces et al., 2010).
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142 Discussion hypoglycemic and dia
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144 Discussion transcription factor
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Summary 1. Insulin induced hypoglyc
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148 Summary specific antibodies con
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150 Summary 16. Transcription facto
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References Abdelmalik PA, Shannon P
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Akwa Y, Ladurelle N, Covey F, Bauli
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Arison RN, Ciaccio EI, Glitzer MS,
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Brezenoff HE, Xiao YF. (1986). Acet
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Caulfield MP, Birdsall NJM. (1998).
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Cherubini E, Martina M, Sciancalepo
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Cryer PE. (2002b). The pathophysiol
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Delgado Esteban M, Almeida A, Bolan
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Dutar P, Nicoll RA. (1989). Pharmac
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Exton JH, Jefferson LS, Butcher RW,
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Frier B. (2000). Hypoglycaemia—cl
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Gerich JE, Schneider V, Dippe SE, L
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Golding DW, Pow DV. (1990). Neurose
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Haddad GG, Jiang C. (1993). Mechani
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Page 265 and 266: Body weight (gm) 300 250 200 150 10
Page 267 and 268: Figure-3 Blood glucose levels at di
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Page 271 and 272: Figure-7 Scatchard analysis of [ 3
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Figure--49 α7 nicotinic acetylchol
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Figure-51 Scatchard analysis of [ 3
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Figure-55 Real Time PCR amplificati
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Figure--69 Muscarinic M1 receptor e
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Figure--71 α7 nicotinic acetylchol
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Figure--91 Muscarinic M3 receptor e
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C Figure--93 GABAAα1 receptor expr
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Figure-101 Real Time PCR amplificat
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Figure—113 Muscarinic M3 receptor
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Figure--115 GABAAα1 receptor expre
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Figure-117 Scatchard analysis of [
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Figure-119 Scatchard analysis of [
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Figure-131 Muscarinic M1 receptor e
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C D + IIH Figure-133 GABAAα1 recep
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