Amphetamine and Related Drugs

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There are a number of difficulties dif culties encountered with quantification quanti cation after employing derivatization. derivatization. These include the fact because derivatization is another handling stage in the analytical process, there is always the risk of sample contamination. Furthermore, the assumption is made that the derivatization reactions are ‘complete complete’ and that the corresponding derivatives are stable for the period between derivative formation and analysis. Further factors are that dilutions need to be extremely accurate and precise to obtain reliable numerical data and that derivatization can potentially lead to increases in numerical errors for such data . 4/27/2009 ١١٦
The amphetamines (standards and samples) should be dissolved in methanolic HCl (100 ml of methanol to which 175 µl l of concentrated HCl has been added). A range of standard solutions should be prepared in order to give a range of concentrations above and below that which the street sample is thought to contain, remembering that the latter may only contain between 0 and 5 wt% amphetamine. If necessary, the materials (particularly the case samples) should be sonicated and, following this, centrifuged to remove any solid materials. The supernatant is retained for subsequent analysis. 4/27/2009 ١١٧
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Amphetamine and Related Drugs 4/27/
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Cocaine Amphetamines Methcathinone
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Marijuana Hashish Hashish Oil Canna
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Other Categories Inhalants like amy
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Schedule I amphetamine derivatives
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Schedule III • The drug or other
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Schedule V • The drug or other su
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4/27/2009 ١٥
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As use of amphetamines spread, so d
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To meet the ever-increasing ever in
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The effects of amphetamines, especi
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A colourless, mobile, slowly volati
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Amfetamine Sulfate Synonyms. Amphet
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4/27/2009 ٢٧
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Therapeutic concentration After no
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Toxicity The estimated minimum leth
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Methylenedioxymethamfetamine Stimul
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N,α-Dimethyl Dimethyl-1,3,benzodio
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Colour Test. Marquis Reagent—bla
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Therapeutic concentration 8 healthy
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Toxicity Fatalities with doses of 3
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Metamfetamine Central Stimulant Syn
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Metamfetamine Hydrochloride Propri
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Disposition in the Body Readily abs
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Half-life Half life Plasma half-li
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A viscous, colourless oil. B.p. is
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Disposition in the Body. It is abs
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Methylenedioxyamfetamine Hallucinog
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Why are adulterants and diluants ad
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Sampling and Physical Description o
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Recording the ballistic features of
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Having carried out the control proc
Page 65 and 66: For tableted materials, homogenizat
Page 67 and 68: The sample should be dissolved as f
Page 69 and 70: The pooled sulfuric acid extracts a
Page 71 and 72: Urine analyzed by Test B shows an i
Page 73 and 74: Aspirate off the lower chloroform l
Page 75 and 76: Add 20 ml chloroform and shake for
Page 77 and 78: Transfer the residue to a 3 ml micr
Page 79 and 80: Dissolve the residues in 20 µl l o
Page 81 and 82: Remove the developed plate and allo
Page 83 and 84: Methamphetamine (Methedrine ( Methe
Page 85 and 86: In addition, MDA, MDMA and MDEA giv
Page 87 and 88: Thin-layer Thin layer Chromatograph
Page 89 and 90: Colour test The Marquis test gives
Page 91 and 92: System TC Plates: Plates: Silica ge
Page 93 and 94: System TAE Plates: Plates: Silica g
Page 95 and 96: Location reagents for systems TA, T
Page 97 and 98: Dragendorff spray Yellow, orange, r
Page 99 and 100: Mandelin’s Mandelin s reagent Thi
Page 101 and 102: Acidified potassium permanganate so
Page 103 and 104: Column: DB-5 DB 5 fused silica (30
Page 105 and 106: Column: Chiralcel OD-RH OD RH (150
Page 107 and 108: Definitive De nitive Identification
Page 109 and 110: 4/27/2009 ١٠٩
Page 111 and 112: In order to alleviate this problem,
Page 113 and 114: The reaction (see equation (2.1)) i
Page 115: Quantification Quanti cation of Amp
Page 119 and 120: Derivatization 4/27/2009 ١١٩
Page 121: Mass Spectra 44 91 40 42 65 45 39 4
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Amphetamine and Related Drugs

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