Amphetamine and Related Drugs

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Disposition in the Body. It is absorbed into the blood stream after ingestion and excreted in urine, the majority of the dose unchanged (65% within 3 days). Metabolism occurs by a number of routes: N- demethylation of the parent compound to 3,4– 3,4 methylenedioxyamfetamine (MDA) (7%) with further O- demethylation to 3,4–dihydroxymethamfetamine 3,4 dihydroxymethamfetamine (HHMA) and 3,4–dihydroxyamfetamine 3,4 dihydroxyamfetamine (HHA). Both HHMA and HHA are subsequently O-methylated methylated mainly to 4–hydroxy 4 hydroxy–3– methoxymetamfetamine (HMMA) and 4–hydroxy 4 hydroxy–3– methoxyamfetamine (HMA). These four metabolites are excreted in the urine as the conjugated glucuronide or sulfate metabolites. 4/27/2009 ٣٨
Therapeutic concentration 8 healthy male volunteers, aged between 21 and 31 years old, were administered a 75 mg dose of MDMA. The mean peak plasma concentration was 0.13 mg/L after 1.8 h. Mean peak plasma concentrations of the metabolite, 3,4– 3,4 methylenedioxyamfetamine (MDA), were 7.8 μg/L g/L approximately 5 h after administration. 4/27/2009 ٣٩
Page 1 and 2: Amphetamine and Related Drugs 4/27/
Page 3 and 4: Cocaine Amphetamines Methcathinone
Page 5 and 6: Marijuana Hashish Hashish Oil Canna
Page 7 and 8: Other Categories Inhalants like amy
Page 9 and 10: Schedule I amphetamine derivatives
Page 11 and 12: Schedule III • The drug or other
Page 13 and 14: Schedule V • The drug or other su
Page 15 and 16: 4/27/2009 ١٥
Page 17 and 18: As use of amphetamines spread, so d
Page 19 and 20: To meet the ever-increasing ever in
Page 21 and 22: The effects of amphetamines, especi
Page 23 and 24: A colourless, mobile, slowly volati
Page 25 and 26: Amfetamine Sulfate Synonyms. Amphet
Page 27 and 28: 4/27/2009 ٢٧
Page 29 and 30: Therapeutic concentration After no
Page 31 and 32: Toxicity The estimated minimum leth
Page 33 and 34: Methylenedioxymethamfetamine Stimul
Page 35 and 36: N,α-Dimethyl Dimethyl-1,3,benzodio
Page 37: Colour Test. Marquis Reagent—bla
Page 41 and 42: Toxicity Fatalities with doses of 3
Page 43 and 44: Metamfetamine Central Stimulant Syn
Page 45 and 46: Metamfetamine Hydrochloride Propri
Page 47 and 48: Disposition in the Body Readily abs
Page 49 and 50: Half-life Half life Plasma half-li
Page 51 and 52: A viscous, colourless oil. B.p. is
Page 53 and 54: Disposition in the Body. It is abs
Page 55 and 56: Methylenedioxyamfetamine Hallucinog
Page 57 and 58: Why are adulterants and diluants ad
Page 59 and 60: Sampling and Physical Description o
Page 61 and 62: Recording the ballistic features of
Page 63 and 64: Having carried out the control proc
Page 65 and 66: For tableted materials, homogenizat
Page 67 and 68: The sample should be dissolved as f
Page 69 and 70: The pooled sulfuric acid extracts a
Page 71 and 72: Urine analyzed by Test B shows an i
Page 73 and 74: Aspirate off the lower chloroform l
Page 75 and 76: Add 20 ml chloroform and shake for
Page 77 and 78: Transfer the residue to a 3 ml micr
Page 79 and 80: Dissolve the residues in 20 µl l o
Page 81 and 82: Remove the developed plate and allo
Page 83 and 84: Methamphetamine (Methedrine ( Methe
Page 85 and 86: In addition, MDA, MDMA and MDEA giv
Page 87 and 88: Thin-layer Thin layer Chromatograph
Page 89 and 90:
Colour test The Marquis test gives
Page 91 and 92:
System TC Plates: Plates: Silica ge
Page 93 and 94:
System TAE Plates: Plates: Silica g
Page 95 and 96:
Location reagents for systems TA, T
Page 97 and 98:
Dragendorff spray Yellow, orange, r
Page 99 and 100:
Mandelin’s Mandelin s reagent Thi
Page 101 and 102:
Acidified potassium permanganate so
Page 103 and 104:
Column: DB-5 DB 5 fused silica (30
Page 105 and 106:
Column: Chiralcel OD-RH OD RH (150
Page 107 and 108:
Definitive De nitive Identification
Page 109 and 110:
4/27/2009 ١٠٩
Page 111 and 112:
In order to alleviate this problem,
Page 113 and 114:
The reaction (see equation (2.1)) i
Page 115 and 116:
Quantification Quanti cation of Amp
Page 117 and 118:
The amphetamines (standards and sam
Page 119 and 120:
Derivatization 4/27/2009 ١١٩
Page 121:
Mass Spectra 44 91 40 42 65 45 39 4
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