Amphetamine and Related Drugs
Amphetamine and Related Drugs
Amphetamine and Related Drugs
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Disposition in the Body.<br />
It is absorbed into the blood stream after ingestion <strong>and</strong><br />
excreted in urine, the majority of the dose unchanged (65%<br />
within 3 days). Metabolism occurs by a number of routes: N-<br />
demethylation of the parent compound to 3,4– 3,4<br />
methylenedioxyamfetamine (MDA) (7%) with further O-<br />
demethylation to 3,4–dihydroxymethamfetamine 3,4 dihydroxymethamfetamine (HHMA)<br />
<strong>and</strong> 3,4–dihydroxyamfetamine 3,4 dihydroxyamfetamine (HHA). Both HHMA <strong>and</strong><br />
HHA are subsequently O-methylated methylated mainly to 4–hydroxy 4 hydroxy–3–<br />
methoxymetamfetamine (HMMA) <strong>and</strong> 4–hydroxy 4 hydroxy–3–<br />
methoxyamfetamine (HMA). These four metabolites are<br />
excreted in the urine as the conjugated glucuronide or sulfate<br />
metabolites.<br />
4/27/2009 ٣٨