Amphetamine and Related Drugs

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Increased control measures were initiated in 1965 with amendments to the federal food and drug laws to curb the black market in amphetamines. Many pharmaceutical amphetamine products were removed from the market including all injectable formulations, and doctors prescribed those that remained less freely. Amphetamine products presently marketed include generic and brand name amphetamine (Adderall Adderall®, , Dexedrine®, Dexedrine , Dextrostat®) Dextrostat ) and brand name methamphetamine (Desoxyn ( Desoxyn®). ). 4/27/2009 ١٨
To meet the ever-increasing ever increasing black market demand for amphetamines, clandestine laboratory production has mushroomed. Today, most amphetamines distributed to the black market are produced in clandestine laboratories. Methamphetamine laboratories are, by far, the most frequently encountered clandestine laboratories in the United States. The ease of clandestine synthesis, combined with tremendous profits, has resulted in significant availability of illicit methamphetamine, especially on the West Coast, where abuse of this drug has increased dramatically in recent years. 4/27/2009 ١٩
Page 1 and 2: Amphetamine and Related Drugs 4/27/
Page 3 and 4: Cocaine Amphetamines Methcathinone
Page 5 and 6: Marijuana Hashish Hashish Oil Canna
Page 7 and 8: Other Categories Inhalants like amy
Page 9 and 10: Schedule I amphetamine derivatives
Page 11 and 12: Schedule III • The drug or other
Page 13 and 14: Schedule V • The drug or other su
Page 15 and 16: 4/27/2009 ١٥
Page 17: As use of amphetamines spread, so d
Page 21 and 22: The effects of amphetamines, especi
Page 23 and 24: A colourless, mobile, slowly volati
Page 25 and 26: Amfetamine Sulfate Synonyms. Amphet
Page 27 and 28: 4/27/2009 ٢٧
Page 29 and 30: Therapeutic concentration After no
Page 31 and 32: Toxicity The estimated minimum leth
Page 33 and 34: Methylenedioxymethamfetamine Stimul
Page 35 and 36: N,α-Dimethyl Dimethyl-1,3,benzodio
Page 37 and 38: Colour Test. Marquis Reagent—bla
Page 39 and 40: Therapeutic concentration 8 healthy
Page 41 and 42: Toxicity Fatalities with doses of 3
Page 43 and 44: Metamfetamine Central Stimulant Syn
Page 45 and 46: Metamfetamine Hydrochloride Propri
Page 47 and 48: Disposition in the Body Readily abs
Page 49 and 50: Half-life Half life Plasma half-li
Page 51 and 52: A viscous, colourless oil. B.p. is
Page 53 and 54: Disposition in the Body. It is abs
Page 55 and 56: Methylenedioxyamfetamine Hallucinog
Page 57 and 58: Why are adulterants and diluants ad
Page 59 and 60: Sampling and Physical Description o
Page 61 and 62: Recording the ballistic features of
Page 63 and 64: Having carried out the control proc
Page 65 and 66: For tableted materials, homogenizat
Page 67 and 68: The sample should be dissolved as f
Page 69 and 70:
The pooled sulfuric acid extracts a
Page 71 and 72:
Urine analyzed by Test B shows an i
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Aspirate off the lower chloroform l
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Add 20 ml chloroform and shake for
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Transfer the residue to a 3 ml micr
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Dissolve the residues in 20 µl l o
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Remove the developed plate and allo
Page 83 and 84:
Methamphetamine (Methedrine ( Methe
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In addition, MDA, MDMA and MDEA giv
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Thin-layer Thin layer Chromatograph
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Colour test The Marquis test gives
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System TC Plates: Plates: Silica ge
Page 93 and 94:
System TAE Plates: Plates: Silica g
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Location reagents for systems TA, T
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Dragendorff spray Yellow, orange, r
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Mandelin’s Mandelin s reagent Thi
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Acidified potassium permanganate so
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Column: DB-5 DB 5 fused silica (30
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Column: Chiralcel OD-RH OD RH (150
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Definitive De nitive Identification
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4/27/2009 ١٠٩
Page 111 and 112:
In order to alleviate this problem,
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The reaction (see equation (2.1)) i
Page 115 and 116:
Quantification Quanti cation of Amp
Page 117 and 118:
The amphetamines (standards and sam
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Derivatization 4/27/2009 ١١٩
Page 121:
Mass Spectra 44 91 40 42 65 45 39 4
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