Amphetamine and Related Drugs

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Amphetamines are generally taken orally or injected. However, the addition of "ice," the slang name for crystallized methamphetamine hydrochloride, has promoted smoking as another mode of administration. Just as "crack" is smokable cocaine, "ice" is smokable methamphetamine. Methamphetamine, in all its forms, is highly addictive and toxic. 4/27/2009 ٢٠
The effects of amphetamines, especially methamphetamine, are similar to cocaine, but their onset is slower and their duration is longer. In contrast to cocaine, which is quickly removed from the brain and is almost completely metabolized, methamphetamine remains in the central nervous system longer, and a larger percentage of the drug remains unchanged in the body, producing prolonged stimulant effects. Chronic abuse produces a psychosis (severe mental disorder), picking at the skin, and visual hallucinations. These psychotic symptoms can persist for months and even years after use of these drugs has ceased and may be related to their neurotoxic effects. Violent and erratic behavior is frequently seen among chronic abusers of amphetamines, especially methamphetamine. 4/27/2009 ٢١
Page 1 and 2: Amphetamine and Related Drugs 4/27/
Page 3 and 4: Cocaine Amphetamines Methcathinone
Page 5 and 6: Marijuana Hashish Hashish Oil Canna
Page 7 and 8: Other Categories Inhalants like amy
Page 9 and 10: Schedule I amphetamine derivatives
Page 11 and 12: Schedule III • The drug or other
Page 13 and 14: Schedule V • The drug or other su
Page 15 and 16: 4/27/2009 ١٥
Page 17 and 18: As use of amphetamines spread, so d
Page 19: To meet the ever-increasing ever in
Page 23 and 24: A colourless, mobile, slowly volati
Page 25 and 26: Amfetamine Sulfate Synonyms. Amphet
Page 27 and 28: 4/27/2009 ٢٧
Page 29 and 30: Therapeutic concentration After no
Page 31 and 32: Toxicity The estimated minimum leth
Page 33 and 34: Methylenedioxymethamfetamine Stimul
Page 35 and 36: N,α-Dimethyl Dimethyl-1,3,benzodio
Page 37 and 38: Colour Test. Marquis Reagent—bla
Page 39 and 40: Therapeutic concentration 8 healthy
Page 41 and 42: Toxicity Fatalities with doses of 3
Page 43 and 44: Metamfetamine Central Stimulant Syn
Page 45 and 46: Metamfetamine Hydrochloride Propri
Page 47 and 48: Disposition in the Body Readily abs
Page 49 and 50: Half-life Half life Plasma half-li
Page 51 and 52: A viscous, colourless oil. B.p. is
Page 53 and 54: Disposition in the Body. It is abs
Page 55 and 56: Methylenedioxyamfetamine Hallucinog
Page 57 and 58: Why are adulterants and diluants ad
Page 59 and 60: Sampling and Physical Description o
Page 61 and 62: Recording the ballistic features of
Page 63 and 64: Having carried out the control proc
Page 65 and 66: For tableted materials, homogenizat
Page 67 and 68: The sample should be dissolved as f
Page 69 and 70: The pooled sulfuric acid extracts a
Page 71 and 72:
Urine analyzed by Test B shows an i
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Aspirate off the lower chloroform l
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Add 20 ml chloroform and shake for
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Transfer the residue to a 3 ml micr
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Dissolve the residues in 20 µl l o
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Remove the developed plate and allo
Page 83 and 84:
Methamphetamine (Methedrine ( Methe
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In addition, MDA, MDMA and MDEA giv
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Thin-layer Thin layer Chromatograph
Page 89 and 90:
Colour test The Marquis test gives
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System TC Plates: Plates: Silica ge
Page 93 and 94:
System TAE Plates: Plates: Silica g
Page 95 and 96:
Location reagents for systems TA, T
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Dragendorff spray Yellow, orange, r
Page 99 and 100:
Mandelin’s Mandelin s reagent Thi
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Acidified potassium permanganate so
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Column: DB-5 DB 5 fused silica (30
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Column: Chiralcel OD-RH OD RH (150
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Definitive De nitive Identification
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4/27/2009 ١٠٩
Page 111 and 112:
In order to alleviate this problem,
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The reaction (see equation (2.1)) i
Page 115 and 116:
Quantification Quanti cation of Amp
Page 117 and 118:
The amphetamines (standards and sam
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Derivatization 4/27/2009 ١١٩
Page 121:
Mass Spectra 44 91 40 42 65 45 39 4
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Amphetamine and Related Drugs

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