Amphetamine and Related Drugs

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After the administration of a single oral dose of 1.5 mg/kg body weight MDMA to 2 patients, plasma and urine samples were collected over periods of 9 and 22 h, respectively. Peak plasma concentrations of MDMA and MDA were 331 μg/L g/L after 2 h and 15 μg/L g/L after 6.3 h, respectively. Peak concentrations of 28.1 μg/L g/L MDMA in urine appeared after 21.5 h. Up to 2.3 μg/L g/L MDA, 35.1 μg/L g/L HMMA, and 2.1 μg/L g/L HMA were measured within 16 to 21.5 h, also in urine. 4/27/2009 ٤٠
Toxicity Fatalities with doses of 300 mg have been reported. Capable of causing severe toxicity and the pattern of acute toxicity is due to the circumstances in which it is misused. A lethal concentration of 0.35 to 0.50 mg/L in serum has been noted although some overdose cases report concentrations 10 times this amount, without fatality. 4/27/2009 ٤١
Page 1 and 2: Amphetamine and Related Drugs 4/27/
Page 3 and 4: Cocaine Amphetamines Methcathinone
Page 5 and 6: Marijuana Hashish Hashish Oil Canna
Page 7 and 8: Other Categories Inhalants like amy
Page 9 and 10: Schedule I amphetamine derivatives
Page 11 and 12: Schedule III • The drug or other
Page 13 and 14: Schedule V • The drug or other su
Page 15 and 16: 4/27/2009 ١٥
Page 17 and 18: As use of amphetamines spread, so d
Page 19 and 20: To meet the ever-increasing ever in
Page 21 and 22: The effects of amphetamines, especi
Page 23 and 24: A colourless, mobile, slowly volati
Page 25 and 26: Amfetamine Sulfate Synonyms. Amphet
Page 27 and 28: 4/27/2009 ٢٧
Page 29 and 30: Therapeutic concentration After no
Page 31 and 32: Toxicity The estimated minimum leth
Page 33 and 34: Methylenedioxymethamfetamine Stimul
Page 35 and 36: N,α-Dimethyl Dimethyl-1,3,benzodio
Page 37 and 38: Colour Test. Marquis Reagent—bla
Page 39: Therapeutic concentration 8 healthy
Page 43 and 44: Metamfetamine Central Stimulant Syn
Page 45 and 46: Metamfetamine Hydrochloride Propri
Page 47 and 48: Disposition in the Body Readily abs
Page 49 and 50: Half-life Half life Plasma half-li
Page 51 and 52: A viscous, colourless oil. B.p. is
Page 53 and 54: Disposition in the Body. It is abs
Page 55 and 56: Methylenedioxyamfetamine Hallucinog
Page 57 and 58: Why are adulterants and diluants ad
Page 59 and 60: Sampling and Physical Description o
Page 61 and 62: Recording the ballistic features of
Page 63 and 64: Having carried out the control proc
Page 65 and 66: For tableted materials, homogenizat
Page 67 and 68: The sample should be dissolved as f
Page 69 and 70: The pooled sulfuric acid extracts a
Page 71 and 72: Urine analyzed by Test B shows an i
Page 73 and 74: Aspirate off the lower chloroform l
Page 75 and 76: Add 20 ml chloroform and shake for
Page 77 and 78: Transfer the residue to a 3 ml micr
Page 79 and 80: Dissolve the residues in 20 µl l o
Page 81 and 82: Remove the developed plate and allo
Page 83 and 84: Methamphetamine (Methedrine ( Methe
Page 85 and 86: In addition, MDA, MDMA and MDEA giv
Page 87 and 88: Thin-layer Thin layer Chromatograph
Page 89 and 90: Colour test The Marquis test gives
Page 91 and 92:
System TC Plates: Plates: Silica ge
Page 93 and 94:
System TAE Plates: Plates: Silica g
Page 95 and 96:
Location reagents for systems TA, T
Page 97 and 98:
Dragendorff spray Yellow, orange, r
Page 99 and 100:
Mandelin’s Mandelin s reagent Thi
Page 101 and 102:
Acidified potassium permanganate so
Page 103 and 104:
Column: DB-5 DB 5 fused silica (30
Page 105 and 106:
Column: Chiralcel OD-RH OD RH (150
Page 107 and 108:
Definitive De nitive Identification
Page 109 and 110:
4/27/2009 ١٠٩
Page 111 and 112:
In order to alleviate this problem,
Page 113 and 114:
The reaction (see equation (2.1)) i
Page 115 and 116:
Quantification Quanti cation of Amp
Page 117 and 118:
The amphetamines (standards and sam
Page 119 and 120:
Derivatization 4/27/2009 ١١٩
Page 121:
Mass Spectra 44 91 40 42 65 45 39 4
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