Combined Actions and Interactions of Chemicals in Mixtures

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Ramsey JC and Andersen ME (1984). A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol Appl Pharmacol, 73, 159-175. Rao NM, Joshi NN, Shinde SR, Advani SH and Ghosh SN (1996). Premature separation of centromere and aneuploidy: an indicator of high risk in unaffected individuals from familial breast cancer families. Eu J Cancer Prev, 5, 343-350. Raymond E, Djelloul S, Buquet-Fagot C, Mester J and Gespach C (1996). Synergy between the non-classical thymidylate synthase inhibitor AG337 (Thymitaq) and cisplatin in human colon and ovarian cancer cells. Anticancer Drugs, 7, 752-757. Reddy BS, Rao CV and Seibert K (1996). Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis. Cancer Res, 56, 4566-4569. Renwick AG (1991). Safety factors and establishment of acceptable daily intakes. Food Additives and Contaminants, 8, 135-150. Renwick AG (1993). Data-derived safety factors for the evaluation of food additives and environmental contaminants. Food Additives and Contaminants, 10, 275-305 Reffstrup TK (2002). Combined actions of pesticides in food. Ministeriet for Fødevarer, Landbrug og Fiskeri, Fødevaredirektoratet. FødevareRapport 2002:19. ISBN: 87-91189-54-3. Rivedal E and Sanner T (1980). Synergistic effect on morphological transformation of hamster embryo cells by nickel sulfate and benz(a)pyrene. Cancer Lett, 8, 203- 208. Roemer E, Anton HJ and Kindt R (1993). Cell proliferation in the respiratory tract of the rat after acute inhalation of formaldehyde or acrolein. J Appl Toxicol, 13, 103- 107. Romert T and Jenssen D (1987). Mechanism of N-acetylcysteine (NAC) and other thiols as both positive and negative modifiers of MMNG-induced mutagenicity in V79 Chinese hamster cells. Carcinogenesis, 8, 1531-1535. Ross MK, Said B and Shank RC (2000). DNA-damaging effects of genotoxins i mixture: modulation of covalent binding to DNA. Toxicol Sci, 53(2), 224-36. Rugen PJ, Stern CD and Lamm SH (1989). Comparative carcinogenicity of the PAH as a basis for acceptable exposure levels (AELs) in drinking water. Regul Toxicol Pharmacol, 9, 273. Safe SH (1998). Hazard and risk assessment of chemical mixtures using the toxic equivalence factor approach. Environ Health Perspect, 106, Suppl 4,1051-1058. Sagai M and Ichinose T (1991). Biochemical effects of combined gases of nitrogen dioxide and ozone. IV. Changes of lipid peroxidation and antioxidative protection systems in rat lungs upon life span exposure. Toxicology, 66, 121-132. Said B, Ross MK, Hamade AK, Matsumoto DC and Shank RC (1999). DNAdamaging effects of genotoxins in mixture: nonadditive effects of aflatoxin B1 and N-acetylaminofluorene on their mutagenicity in Salmonella typhimurium. Toxicol Sci, 52, 226-231. 152
Sakai K, Nakajima J, Niimura M, Uchida R and Yamane Y (1994). Enhancement by zinc acetate of 1-nitropyrene binding to DNA in the hypoxanthine-xanthine oxidase system. Bull Environ Contam Toxicol, 54, 142-149. Salaman MH and Roe FJC (1953). Incomplete carcinogens: ethyl carbamate (urethane) as an initiator of skin tumour formation in the mouse. Br J Cancer, 7, 472-481. Sankaranarayanan R, Mathew B, Varghese C, Sudhakaran PR, Menon V, Jayadeep A, Nair MK, Mathews C, Mahalingam TR, Balaram P and Nair PP (1997). Chemoprevention of oral leukoplakia with vitamin A and beta-carotene: an assessment. Oral Oncol, 33, 231-236. Schaumloffel N and Gebel T (1998). Heterogeneity of the DNA damage provoked by antimony and arsenic. Mutagenesis, 13, 281-286. Scherer E, Feringa AW and Emmelot P (1984). Initiation-promotion-initiation. Induction of neoplastic foci within islands of precancerous liver cells in the rat. IARC Sci Publ, 57-66. Scherer E (1984). Neoplastic progression in experimental hepatocarcinogenesis. Biochim Biophys Acta, 738, 219-236. Schneider K, Roller R, Kalberlah F and Schuhmacher-Wolz U (2002). Cancer risk assessment for oral exposure to PAH mixtures. J Appl Toxicol, 22, 73-83. Schoor WP, Williams DE and Takahashi N (1991). The induction of cytochrome P-450-IA1 in juvenile fish by creosote-contaminated sediment. Arch Environ Contam Toxicol, 20, 497-504. Schwartz J and Shklar G (1987). Regression of experimental hamster cancer by beta-carotene and algae extracts. J Oral Maxillofac Surg, 45, 510-515. Seabaugh VM, Chambers WA, Green S, Gupta KC, Hill RN, Hurley PM, Lambert LA, Lee CC, Lee JK, Liu PT et al. (1993). Use of ophthalmic topical anaesthetics. Fd Chem Toxicol, 31, 95-98. Seed J, Brown RP, Olin SS and Foran JA (1995). Chemical mixtures: Current risk assessment methodologies and future directions. Reg Toxicol Pharmacol, 22, 76- 94. Sellakumar AR, Snyder CA, Solomon JJ and Albert RE (1985). Carcinogenicity of formaldehyde and hydrogen chloride in rats. Toxicol Appl Pharmacol, 81, 401-406. Semchuk KM, Love EJ and Lee RG (1992). Parkinson's disease and exposure to agricultural work and pesticide chemicals. Neurology, 42, 1328-1335. Shichi H, Mahalak SM, Sakamoto S and Sugiyama T (1991). Immunocytochemical study of phenobarbital- and 3-methylcholanthrene-inducible cytochrome P450 isozymes in primary cultures of porcine ciliary epithelium. Current Eye research, 10, 779-788. Shopsis C and Sathe S (1984). Uridine uptake inhibition as a cytotoxicity test: correlations with the Draize test. Toxicology, 29, 195-206. 153
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Combined Actions and Interactions o
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Contents CONTENTS 3 PREFACE 6 SAMME
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7.2.4 Test systems 85 7.2.5 In vitr
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Sammenfatning og konklusioner Indle
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er ingen viden om, hvorledes den ko
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estemt biologisk respons (ED10, ED2
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vivo. The COMET-assay in vivo and g
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and antagonistic effects may be see
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1 Introduction Prepared by John Chr
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Table 1.3.1: Classification of comb
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Physicochemical interactions will t
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US EPA (1986) applied the concept o
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2.4 Test strategies to assess combi
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Figure 2.4.3.1. Isobologram of two
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CI = d1 /D1 = 1 In this case the is
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2.5 Toxicological test methods When
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3 General concepts in the risk asse
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NOAEL, this indicates that the subs
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of uncertainty i.e. differences in
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describe toxicities that appears to
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should be estimated for all endpoin
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1,2,3,6,7,8-HxCDF 0.1 1,2,3,7,8,9-H
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shows the pronounced influence of t
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Table 4.3.1 Estimates of carcinogen
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Figure 4.4.1.1. Scheme for safety e
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obvious ranking of individual const
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4.5 Approach for assessment of join
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4.6 Approaches currently used by re
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no internationally accepted procedu
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Figure 4.6.3.1 Flow chart of the ri
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octyltin dichloride). A number of a
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stannous chloride and cadmium chlor
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seen in the animals from the 1000x
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c TCTFP = 1,1,2-trichloro-3,3,3-tri
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6 Interactions in toxicokinetics Pr
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once more exposed and the kinetics
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Dermis The dermis consists of a sup
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7.1.3 Ocular irritancy 7.1.3.1 Comp
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Another in vitro test for ocular ir
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lipid peroxidation was observed, wh
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mixture. These interactions may dev
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0.6% of live births in humans. In s
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DNA, and that the cell was capable
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(Sorsa et al. 1994, Myslak & Kosmid
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Four inhibitors of DNA topoisomeras
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cyclophosphamide-metabolising enzym
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Nickel compounds are carcinogenic t
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7.2.8 Conclusion As shown in this r
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Since no compounds are known to cau
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In a more mechanistic sense, promot
Page 102 and 103: Several inhibitors of tumour promot
Page 104 and 105: Table 7.4.1.1 Overview of in vivo t
Page 106 and 107: analysis was used to predict the hi
Page 108 and 109: interaction of TCDD and retinoic ac
Page 110 and 111: and now includes compounds as diver
Page 112 and 113: Furthermore, the estrogenic effects
Page 114 and 115: Dose of A (arbitrary units) 10 8 6
Page 116 and 117: chance or experimental error. One w
Page 118 and 119: 7.6.2.3 Receptors A receptor is a b
Page 120 and 121: 7.6.5.2 Kindling Kindling is the ph
Page 122 and 123: Science Institute (RSI) have conven
Page 124 and 125: eaction with sulfhydryl groups). Th
Page 126 and 127: 7.7.1.3 Mechanisms of immunotoxicit
Page 128 and 129: tested separately. This is a phenom
Page 130 and 131: In practical life an allergen may b
Page 132 and 133: 8.3 Conference proceedings Proceedi
Page 134 and 135: with combinations of environmental
Page 136 and 137: Boyd MR, Statham CM and Longo NS (1
Page 138 and 139: De Wall EJ, Schuurman HJ and Van Lo
Page 140 and 141: theoretical considerations and a su
Page 142 and 143: Groten JP, Sinkeldam EJ, Muys T, Lu
Page 144 and 145: Howes D, Guy R, Hadgraft J, Heyling
Page 146 and 147: cytochrome P450 1A2 expressed in Am
Page 148 and 149: Lison D, Carbonnelle P, Mollo L, La
Page 150 and 151: Narotsky MG, Weller EA, Chinchilli
Page 154 and 155: Silva E, Rajapakse N and Kortenkamp
Page 156 and 157: Leeuwen FXR, Liem AKD, Nolt C, Pete
Page 158: Wlodarczyk B, Biernacki B, Minta M,
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