Combined Actions and Interactions of Chemicals in Mixtures

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Wlodarczyk B, Biernacki B, Minta M, Kozaczynski W and Juszkiewicz T (1995). Male golden hamster in male reproductive toxicology testing: Assessment of protective activity of selenium in acute cadmium intoxication. Bull Environ Contam Toxicol, 54, 907-912. Wurpel JND, Hirt PC and Bidanset JH (1993). Amygdala kindling in immature rats: Proconvulsant effect of the organophosphate insecticide – chlorpyrifos. Neurotoxicol, 14, 429-436. Yamada M, Matsui K, Sofuni T and NohmiT (1997). New tester strains of Salmonella typhimurium lacking o6-methylguanine DNA methyltransferases and highly sensitive to mutagenic alkylating agents. Mutat Res, 381, 15-24. Yang RSH (1994). Introduction to the toxicology of chemical mixtures. In Ed. Yang RS: Toxicology of Chemical Mixtues. Case Studies, Mechanisms, and Novel Approaches. Academic Press, San Diego, London, pp. 1-9. Yang RSH (1994). Toxicology of Chemical Mixtures - Case Studies, Mechanisms, and Novel Approaches. Yang RSH (ed.). Academic Press; San Diego, New York, Boston, London, Sydney, Tokyo, Toronto. Yang RS, El-Masri HA, Thomas RS, Constan AA and Tessari JD (1995). The application of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling for exploring risk assessment approaches for chemical mixtures. Toxicol Lett, 79, 193-200. Yokoyama E, Ichikawa I and Kawai K (1980). Does nitrogen dioxide modify the respiratory effects of ozone? In Nitrogen Oxides and Their Effects on Health, S. D. Lee, Ed. Ann Arbor Science Publishers. Ann Arbor, MI. pp. 217-229. Yu MW, Lien JP, Liaw YF and Chen CJ (1996). Effects of multiple risk factors for hepatocellular carcinoma on formation of aflatoxin B1-DNA adducts. Cancer Epidemiol Biomarkers Prev, 5, 613-619. Yuspa SH, Lichti U, Ben T, Patterson E, Hennings H, Slaga TJ, Colburn N and Kelsey W (1976). Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell cultures. Nature, 262, 402-404. Zayed J, Ducic S, Campanella G, Panisset JC, Andre P, Masson H and Roy M (1990). Environmental factors in the etiology of Parkinson's disease. Can J Neurol Sci, 17, 286-291. Zhai H, Willard P and Maibach HI (1998). Evaluating skin-protective materials against contact irritants and allergens. An in vivo screening human model. Contact Dermatitis, 38(3), 155-158. 158
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Combined Actions and Interactions o
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Contents CONTENTS 3 PREFACE 6 SAMME
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7.2.4 Test systems 85 7.2.5 In vitr
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Sammenfatning og konklusioner Indle
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er ingen viden om, hvorledes den ko
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estemt biologisk respons (ED10, ED2
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vivo. The COMET-assay in vivo and g
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and antagonistic effects may be see
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1 Introduction Prepared by John Chr
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Table 1.3.1: Classification of comb
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Physicochemical interactions will t
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US EPA (1986) applied the concept o
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2.4 Test strategies to assess combi
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Figure 2.4.3.1. Isobologram of two
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CI = d1 /D1 = 1 In this case the is
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2.5 Toxicological test methods When
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3 General concepts in the risk asse
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NOAEL, this indicates that the subs
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of uncertainty i.e. differences in
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describe toxicities that appears to
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should be estimated for all endpoin
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1,2,3,6,7,8-HxCDF 0.1 1,2,3,7,8,9-H
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shows the pronounced influence of t
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Table 4.3.1 Estimates of carcinogen
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Figure 4.4.1.1. Scheme for safety e
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obvious ranking of individual const
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4.5 Approach for assessment of join
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4.6 Approaches currently used by re
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no internationally accepted procedu
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Figure 4.6.3.1 Flow chart of the ri
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octyltin dichloride). A number of a
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stannous chloride and cadmium chlor
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seen in the animals from the 1000x
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c TCTFP = 1,1,2-trichloro-3,3,3-tri
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6 Interactions in toxicokinetics Pr
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once more exposed and the kinetics
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Dermis The dermis consists of a sup
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7.1.3 Ocular irritancy 7.1.3.1 Comp
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Another in vitro test for ocular ir
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lipid peroxidation was observed, wh
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mixture. These interactions may dev
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0.6% of live births in humans. In s
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DNA, and that the cell was capable
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(Sorsa et al. 1994, Myslak & Kosmid
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Four inhibitors of DNA topoisomeras
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cyclophosphamide-metabolising enzym
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Nickel compounds are carcinogenic t
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7.2.8 Conclusion As shown in this r
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Since no compounds are known to cau
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In a more mechanistic sense, promot
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Several inhibitors of tumour promot
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Table 7.4.1.1 Overview of in vivo t
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analysis was used to predict the hi
Page 108 and 109: interaction of TCDD and retinoic ac
Page 110 and 111: and now includes compounds as diver
Page 112 and 113: Furthermore, the estrogenic effects
Page 114 and 115: Dose of A (arbitrary units) 10 8 6
Page 116 and 117: chance or experimental error. One w
Page 118 and 119: 7.6.2.3 Receptors A receptor is a b
Page 120 and 121: 7.6.5.2 Kindling Kindling is the ph
Page 122 and 123: Science Institute (RSI) have conven
Page 124 and 125: eaction with sulfhydryl groups). Th
Page 126 and 127: 7.7.1.3 Mechanisms of immunotoxicit
Page 128 and 129: tested separately. This is a phenom
Page 130 and 131: In practical life an allergen may b
Page 132 and 133: 8.3 Conference proceedings Proceedi
Page 134 and 135: with combinations of environmental
Page 136 and 137: Boyd MR, Statham CM and Longo NS (1
Page 138 and 139: De Wall EJ, Schuurman HJ and Van Lo
Page 140 and 141: theoretical considerations and a su
Page 142 and 143: Groten JP, Sinkeldam EJ, Muys T, Lu
Page 144 and 145: Howes D, Guy R, Hadgraft J, Heyling
Page 146 and 147: cytochrome P450 1A2 expressed in Am
Page 148 and 149: Lison D, Carbonnelle P, Mollo L, La
Page 150 and 151: Narotsky MG, Weller EA, Chinchilli
Page 152 and 153: Ramsey JC and Andersen ME (1984). A
Page 154 and 155: Silva E, Rajapakse N and Kortenkamp
Page 156 and 157: Leeuwen FXR, Liem AKD, Nolt C, Pete
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