Combined Actions and Interactions of Chemicals in Mixtures

Figure 4.4.2.2 Scheme for safety evaluation of complex chemical mixtures
Complex mixtures
Mixtures readily available
for testing in their enterity
Mixture unavailable for
testing in its entirety
"Top-ten" classes of chemicals
readily identifiable
"Top-ten" chemicals
readily identifiable
Testing in their
entirety indicated
Identification of
the "top-ten" chemicals
Lump "top-ten" classes of
chemicals to "pseudo
top-ten" chemicals
Consider "top-ten" chemicals
as a simple mixture
Adverse effects
found in adequate
and relevant studies
No adverse effects
found in adequate
and relevant studies
Consider "top-ten" chemicals
as a simple mixture
Consider "pseudo top-ten"
chemicals as a
simple mixture
Data should be useful
for risk assessment
Toxicity profile indicates
fractionation according
to toxicity
Toxicity profile
satisfactorily characterized
Data should be useful
for risk assessment
Data should be useful
for risk assessment
Data should be useful
for risk assessment
Identification of the chemical,
group of chemicals or fraction
responsible for toxicity
Data should be useful
for risk assessment
Data should be useful
for risk assessment
52