POTASSIUM CHLORIDE CAS N°: 7447-40-7

OECD SIDS POTASSIUM CHLORIDE
Date: 30-MAR-2003
5. Toxicity Substance ID: 7447-40-7
Strain:
Sex:
not stated
Number of
Animals: 6
Vehicle:
other: none
Value:
4000 mg/kg body weight
Method:
other: acute toxicity
Year: 1955 GLP: no data
Test substance: as prescribed by 1.1-1.4, purity: chemical grade
Remarks:
KCl was administered orally to six sheep
maintained on a normal ration, in single doses of
2, 3, and 4 g/kg body weight, and observed for
toxic signs. The Minimum Lethal Dose (MLD) in
nonfasted animals was 4 g/kg body weight. Two
sheep receiving this dose has a time to death of
40 to 85 minutes. Salivation, vomiting, heart
throbbing, accelerated breathing, mydriasis,
staggering walk, spasms, and finally coma preceded
death. Sublethal doses of KCl caused depression,
refusion to eat, polyuria, increased respiration
rate, and rapid pulse for a period of 4 to 6
hours, but the animals recovered without any
further signs of toxicity.
Reliability: (3) not reliable
Flag:
non confidential
28-FEB-2001 (69)
Type:
LDL0
Species:
goat
Strain:
Sex:
not stated
Number of
Animals: not stated
Vehicle:
other: none
Value:
4000 mg/kg body weight
Method:
other: acute toxicity
Year: 1955 GLP: no data
Test substance: as prescribed by 1.1-1.4, purity: chemical grade
Remarks:
Acute oral toxicity of KCl was studied for
goats on salt-poor diet (no added NaCl for 1.5
months) as compared with animals on a normal
ration. A single oral dose of 4 g/kg body weight
caused death within 35 to 85 minutes in the saltdeficient
animals, whereas those on a normal feed
ration survived. Clinical signs of toxicity in
animals given lethal doses: Vomiting, polyuria,
tetanic spasms of muscles of extremities,
accelerated respiration and pulse. At autopsy, the
kidneys were swollen, the heart muscle was flabby,
and the rumen, reticulum, abomasum and duodenum
mucosae were hyperemic.
Reliability: (3) not reliable
Flag:
non confidential
28-FEB-2001 (69)
Type:
Species:
Exposure time:
Value:
Method:
LD50
rat
2600 mg/kg
other: acute toxicity
UNEP PUBLICATIONS 65