POTASSIUM CHLORIDE CAS N°: 7447-40-7

OECD SIDS POTASSIUM CHLORIDE
Date: 30-MAR-2003
5. Toxicity Substance ID: 7447-40-7
solvent for the test chemical, and was negative
under all test conditions.
Source:
Norsk Hydro ASA
Reliability: (1) reliable without restriction
Flag:
Key study for SIDS
01-MAR-2001 (52)
Type:
chromosome aberration
System of
testing: Chinese Hamster Ovary cells (CHO)
Concentration: 0, 70, 80, 90 mM
Metabolic
activation: without
Results: Cytotoxicity conc: Without metabolic activation: 90
mM
without metabolic activation: positive
Method:
other
Year: 1988 GLP: no data
Test substance: as prescribed by 1.1-1.4, purity: commercial grade
Remarks:
50 cells were scored for each dose. The osmotic
pressure of the media was 300, 430, 445 and 465
mOsm/kg H 2 O for 0, 70, 80 and 90 mM KCl,
respectively. The survival in % was 100, 60, 45
and 25 for 0, 70, 80 and 90 mM KCl, respectively.
After 24 hours the % aberrant cells were 4, 10, 28
and 30 for 0, 70, 80 and 90 mM KCl, respectively.
After 42 hours the % aberrant cells were 2, 6, 4
and 23 for 0, 70, 80 and 90 mM KCl, respectively.
In the OECD guidelines the recommended limit
concentration is 10 mM, and in this chromosomal
aberration test positive results were reported
around 80 mM KCl.
Source:
Norsk Hydro ASA
Reliability: (2) reliable with restriction
Flag:
Key study for SIDS
01-MAR-2001 (16)
Type:
System of
testing:
Concentration:
Metabolic
activation:
Results:
mammalian cell gene mutation (V79 cells),
chromosome aberration tests (CHO cells), and
Unscheduled DNA synthesis (HeLa cells)
Chinese Hamster V79 cells (V79), Chinese hamster
Ovary cells (CHO), HeLa S3 cells (HeLa)
0-300 mM
with S9 liver homogenate, and without
Cytotoxicity conc:
With metabolic activation: 37.5 mM (V79), 150 mM
(CHO)
Without metabolic activation: 100 mM (V79), 75 mM
(CHO)
Genotoxic effects:
With metabolic activation: Genmutation; 3 to 7 fold
increase in the mutation frequency. The increase
was observed at toxic and nontoxic doses of KCl.
Chromosomal aberration; at 200 mM 6.9 % of the
cells had aberrations in the presence of slight
toxicity. Unscheduled DNA Synthesis; No increase in
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