POTASSIUM CHLORIDE CAS N°: 7447-40-7

OECD SIDS POTASSIUM CHLORIDE
Date: 30-MAR-2003
5. Toxicity Substance ID: 7447-40-7
General parental/maternal toxicity:
No effects seen in survival, total number of corpora
lutea, implant sites, resorptions, soft tissue
observations (urogenital tract), or live offspring.
Toxicity to offspring:
No effects seen in survival, sex ratio, average
offspring weight, external congenital abnormalities,
soft tissue defects (cleft palate), or skeletal
defects (sternebrae, ribs, vertebrae, skull and
extremities).
No further information was included in the study
report.
Source:
Norsk Hydro ASA
Reliability: (2) reliable with restrictions
Flag:
Key study for SIDS
01-MAR-2001 (31)
Type:
Developmental toxicity study
Species: rat Sex: female
Strain:
Virgin adult Wistar
Route of admin.: oral intubation
Exposure Period: ten days (day 6 to 15 of gestation)
Frequency of
treatment: single daily administration by oral intubation
Premating Exposure Period
male:
none
female:
none
Duration of test: sacrifice on the 20 th day
Doses:
3.1, 14.4, 66.8, 310.0 mg/kg body weight
Control Group: yes
NOAEL Parental: > 310 mg/kg
NOAEL F1 Offspr.: > 310 mg/kg
Method:
other
Year: 1975 GLP: no data
Test substance: as prescribed by 1.1-1.4, purity: not stated. Vehicle was
water.
Remark:
Groups of 21-24 experimental animals were used.
Female rats were mated with young adult male rats,
and observation of vaginal plug was considered day 0
of gestation. Body weights were recorded on days 0,
6, 11, 15 and 20 of gestation. The dams were
subjected to Caesarean section on gestation day 20.
Post exposure observation period: 5 days. The
urogenital tract of each dam was examined in detail
for anatomical normality.
The administration of up to 310 mg/kg body weight of
KCl to pregnant rats for 10 consecutive days had no
clear discernible effects on nidation or on maternal
or offspring survival. The number of abnormalities
seen in either soft or skeletal tissues of the test
group did not differ from the controls.
General parental toxicity:
No effects seen in survival, total number of corpora
lutea, implant sites, resorptions, soft tissue
observations (urogenital tract), or live offspring.
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