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POTASSIUM CHLORIDE CAS N°: 7447-40-7

POTASSIUM CHLORIDE CAS N°: 7447-40-7

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OECD SIDS <strong>POTASSIUM</strong> <strong>CHLORIDE</strong><br />

Date: 30-MAR-2003<br />

5. Toxicity Substance ID: <strong>7447</strong>-<strong>40</strong>-7<br />

01-MAR-2001 (71)<br />

Type:<br />

LDL0<br />

Species/strain: guinea pig<br />

Route of<br />

Administration: i.a., i.v., i.c.<br />

Exposure time:<br />

Value:<br />

intraarterial: 130 mg/kg<br />

intravenous: 77 mg/kg<br />

intracardial: <strong>40</strong> mg/kg<br />

other: acute toxicity<br />

Method:<br />

Year: 1928 GLP: no data<br />

Test substance: as prescribed by 1.1-1.4, purity: not stated.<br />

Remarks:<br />

Animals were injected 5 % KCl solution (maximum<br />

volume 0.6 ccm).<br />

Source:<br />

Norsk Hydro ASA<br />

Reliability: (2) reliable with restrictions<br />

Flag:<br />

non confidential<br />

01-MAR-2001 (28)<br />

Type:<br />

LD50<br />

Species/strain: mouse<br />

Route of<br />

Administration: i.p.<br />

Exposure time:<br />

Value:<br />

620 mg/kg<br />

Method:<br />

other: acute toxicity<br />

Year: 1963 GLP: no data<br />

Source:<br />

Norsk Hydro ASA<br />

Reliability: (4) not assignable<br />

Original reference could not be checked.<br />

Flag:<br />

without flag<br />

01-MAR-2001 (4)<br />

Type:<br />

LDL0<br />

Species/strain: guinea pig<br />

Route of<br />

Administration: s.c.<br />

Exposure time:<br />

Value:<br />

2550 mg/kg body weight<br />

Method:<br />

other: acute toxicity<br />

Year: 1935 GLP: no data<br />

Source:<br />

Norsk Hydro ASA<br />

Reliability: (4) not assignable<br />

Original reference could not be checked.<br />

Flag:<br />

without flag<br />

01-MAR-2001 (2)<br />

5.2 Corrosiveness and Irritation<br />

5.2.1 Skin Irritation<br />

Species:<br />

humans<br />

Result: A threshold concentration for irritancy of 60 %<br />

was seen when KCl in aqueous solution was in<br />

contact with the skin of volunteers. The threshold<br />

concentration when applied to broken skin for the<br />

same amount of time was 5 %. No grading of the<br />

68<br />

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