POTASSIUM CHLORIDE CAS N°: 7447-40-7

OECD SIDS POTASSIUM CHLORIDE
Date: 30-MAR-2003
5. Toxicity Substance ID: 7447-40-7
skin irritating potential was measured in this
study.
Method:
Chamber scarification test
Year: 1976 GLP: no data
Test substance: no data
Remark:
A forearm test site was criss-crossed scarified by
drawing a needle over the skin with enough pressure
to cleave epidermis without bleeding. The test
agent was applied in an aluminium chamber sealed to
the skin once daily for 3 days.
Source:
Norsk Hydro ASA
Reliability: (3) not reliable
Flag:
non confidential
28-FEB-2001 (34)
5.2.2 Eye Irritation
Species:
rabbit
Result:
Instillation of 500 mg KCl produced a mild
reaction in the rabbit eye at 24 hours.
Method:
other: eye Irritation
Year: 1976 GLP: no data
Test substance: no data
Source:
Norsk Hydro ASA
Reliability: (4) not assignable
Original reference could not be checked.
Flag:
without flag
28-FEB-2001 (3)
5.3 Sensitization
5.4 Repeated Dose Toxicity
Species: rat Sex: male
Strain:
F344/Scl
Route of admin.: oral feed
Exposure period: 2 years
Frequency of
treatment: daily
Post. obs.
period:
none
Doses:
0.25, 1 % and 4 % KCl; 0.11, 0.45 and 1.82 g/kg body
weight/day
Control Group: yes, concurrent no treatment
Results:
NOAEL > 1.82 g/kg body weight/day. The only
treatment related effects seen in rats fed about
0.11-1.82 g/kg body weight/day were gastritis
(inflammation of the stomach linking), an irritant
effect. The percentages of gastritis were 18 % in
the 0.11 and 0.45 g/kg bw/day groups, and 30 % in
the 1.82 g/kg bw/day group, compared to 6 % in the
control group. At the end of the 2 year
experimental period, the survival rates were 64 %
in 0.25 % KCl, 58 % in 1 % KCl, 84 % in 4 % KCl,
and 48 % in control groups. Absolute and relative
organ weights were measured for the following
organs; brain, pituitary, thymus, heart, lung,
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