POTASSIUM CHLORIDE CAS N°: 7447-40-7

OECD SIDS POTASSIUM CHLORIDE
Date: 30-MAR-2003
5. Toxicity Substance ID: 7447-40-7
those of spontaneous tumors in F344/Scl rats. The
only treatment related effect was gastritis, 18 %
in the 0.25%and 1.0% KCl group, and 30% in the 4%
KCl group compared to 6% in the control group.
Source:
Norsk Hydro ASA
Reliability: (2) reliable with restriction
Flag:
non-confidential
01-MAR-2001 (44)
5.8 Toxicity to Reproduction
Remarks:
Source:
Reliability:
Flag:
01-MAR-2001
no studies located
Norsk Hydro ASA
(2) valid with restrictions
non confidential
5.9 Developmental Toxicity/Teratogenicity
Type:
Developmental toxicity study
Species: mice Sex: female
Strain:
virgin adult albino CD-l outbred
Route of admin.: oral intubation
Exposure Period: ten days (day 6 to 15 of gestation)
Frequency of
treatment: single daily administration by oral intubation
Premating Exposure Period
male:
none
female:
none
Duration of test: sacrifice on the 17 th day
Doses:
2.35, 10.9, 50.6, 235.0 mg/kg body weight
Control Group: yes
NOAEL Parental: > 235 mg/kg
NOAEL F1 Offspr.: > 235 mg/kg
Method:
other
Year: 1975 GLP: no data
Test substance: as prescribed by 1.1-1.4, purity: not stated. Vehicle was
water.
Remark:
Groups of 21-24 experimental animals were used.
Female mice were mated with young adult male mice,
and observation of vaginal sperm plug was considered
day 0 of gestation. Body weights were recorded on
days 0, 6, 11, 15 and 17 of gestation. The dams
were subjected to Caesarean section on gestation
day 17. Post exposure observation period: 2 days.
The urogenital tract of each dam was examined in
detail for anatomical normality.
The administration of up to 235 mg/kg body weight
of KCl to pregnant mice for 10 consecutive days had
no effect on nidation or on maternal or offspring
survival. The number of abnormalities seen in
either soft or skeletal tissues of the test group
did not differ from the controls.
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