POTASSIUM CHLORIDE CAS N°: 7447-40-7

OECD SIDS POTASSIUM CHLORIDE
Date: 30-MAR-2003
5. Toxicity Substance ID: 7447-40-7
liver, spleen, pancreas, kidney, adrenal gland,
testis, seminal vesicle and prostate. However, no
statistically significant changes were reported in
any organs at any dose levels.
Nephrotic lesion was predominant in all groups,
including controls. Pathological non-tumerous and
tumors lesions did not indicate any carcinogenic
effects of KCl.
Method:
other: Repeated Dose Toxicity
Year: 1961 GLP: no data
Test substance: as prescribed by 1.1-1.4, purity: commercial grade
Remark:
Groups of 50 rats (male) were exposed to KCl
administered through the food.
Source:
Norsk Hydro ASA
Reliability: (2) reliable with restrictions
Flag:
Key study for SIDS
01-MAR-2001 (44)
Species: rat Sex: female
Strain:
Wistar
Route of admin: oral feed
Exposure period: 105 days
Frequency of
treatment: daily
Post. obs.
period: 1 month
Doses: 5.25 g/kg body weight per day administrated as 2.5
% aqueous solution of KCl
Control Group: yes, concurrent no treatment
Result: Mean heart weight was significantly less (270±34
mg/100 g) and mean kidney weight was significantly
higher (845±112 mg/100 g) than that of control
animals (respectively 324±19 and 731±31 mg/100 g).
Histological studies of the adrenals indicated
hypertrophy in the glomerular zone. All changes
seen were reversible in the control animals.
Method:
other: Repeated Dose Toxicity
Year: 1951 GLP: no data
Test substance: as prescribed by 1.1-1.4, purity: unknown
Remarks:
14 experimental animals and 6 control rats were
fed ad libitum on a diet (Purina laboratory chow)
and a 2.5 % aqueous solution of KCl as the sole
source of fluid. At the end of the exposure
period, 10 animals were terminated, the remaining
4 animals were supplied with tap water in place of
KCl for one further month. At termination of the
study, the heart and kidneys were weighed. The
adrenals and kidneys were prepared for
histological studies which included detection of
ascorbic acid, cholesterol and other lipids.
Source:
Norsk Hydro ASA
Reliability: (2) reliable with restrictions
Flag:
non-confidential
01-MAR-2001 (5)
Species: humans Sex: female
Route of admin: oral feed
Exposure period: 4 week placebo controlled crossover study
70
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