POTASSIUM CHLORIDE CAS NÂ°: 7447-40-7

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OECD SIDS POTASSIUM CHLORIDE Date: 30-MAR-2003 5. Toxicity Substance ID: 7447-40-7 liver, spleen, pancreas, kidney, adrenal gland, testis, seminal vesicle and prostate. However, no statistically significant changes were reported in any organs at any dose levels. Nephrotic lesion was predominant in all groups, including controls. Pathological non-tumerous and tumors lesions did not indicate any carcinogenic effects of KCl. Method: other: Repeated Dose Toxicity Year: 1961 GLP: no data Test substance: as prescribed by 1.1-1.4, purity: commercial grade Remark: Groups of 50 rats (male) were exposed to KCl administered through the food. Source: Norsk Hydro ASA Reliability: (2) reliable with restrictions Flag: Key study for SIDS 01-MAR-2001 (44) Species: rat Sex: female Strain: Wistar Route of admin: oral feed Exposure period: 105 days Frequency of treatment: daily Post. obs. period: 1 month Doses: 5.25 g/kg body weight per day administrated as 2.5 % aqueous solution of KCl Control Group: yes, concurrent no treatment Result: Mean heart weight was significantly less (270±34 mg/100 g) and mean kidney weight was significantly higher (845±112 mg/100 g) than that of control animals (respectively 324±19 and 731±31 mg/100 g). Histological studies of the adrenals indicated hypertrophy in the glomerular zone. All changes seen were reversible in the control animals. Method: other: Repeated Dose Toxicity Year: 1951 GLP: no data Test substance: as prescribed by 1.1-1.4, purity: unknown Remarks: 14 experimental animals and 6 control rats were fed ad libitum on a diet (Purina laboratory chow) and a 2.5 % aqueous solution of KCl as the sole source of fluid. At the end of the exposure period, 10 animals were terminated, the remaining 4 animals were supplied with tap water in place of KCl for one further month. At termination of the study, the heart and kidneys were weighed. The adrenals and kidneys were prepared for histological studies which included detection of ascorbic acid, cholesterol and other lipids. Source: Norsk Hydro ASA Reliability: (2) reliable with restrictions Flag: non-confidential 01-MAR-2001 (5) Species: humans Sex: female Route of admin: oral feed Exposure period: 4 week placebo controlled crossover study 70 UNEP PUBLICATIONS
OECD SIDS POTASSIUM CHLORIDE Date: 30-MAR-2003 5. Toxicity Substance ID: 7447-40-7 Frequency of treatment: Post. obs. period: Doses: daily 1 month 80 mmol KCl/day (approx. 85 mg/kg body weight/day) Control group: yes, concurrent no treatment Result: NOAEL > 85 mg/kg body weight. No significant changes in blood pressure or heart rate. Significant increases in potassium urinary excretion (P
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POTASSIUM CHLORIDE CAS NÂ°: 7447-40-7

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