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<strong>Poster</strong> Sessions<br />
2236. Automatic Measurement of Atrophy Rates in Hippocampal Subfields from Longitudinal High-Resolution T 2 -<br />
Weighted MRI<br />
Sandhitsu Das 1 , Brian Avants 1 , John Pluta 1 , Caryne Craige 1 , Michael Weiner 2 , Susanne Mueller 2 , Paul Yushkevich 1<br />
1 PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2 VA Medical Center, University of<br />
California at San Francisco, San Francisco, CA, United States<br />
2237. Feasibility of Detecting Preclinical Hippocampal Neuronal Cell Loss in Subjects Destined to Develop<br />
Alzheimer’s Disease<br />
Keith R. Thulborn 1 , Debra Fleischman 2 , R. Shah 2 , Ian C. Atkinson 1 , Aiming Lu 1<br />
1 Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States; 2 Rush Alzheimer's Disease<br />
Clinic, Rush University Medical Center,, Chicago, IL<br />
2238. A Novel Events-Based Model for Mapping Disease Progression & Its Application to Familial Alzheimer's<br />
Disease<br />
Hubert Martinus Fonteijn 1 , Matt J. Clarkson 2 , Marc Modat 1 , Josephine Barnes 2 , Manja Lehmann 2 , Sebastien<br />
Ourselin 1 , Nick C. Fox 2 , Daniel C. Alexander 1<br />
1 Computer Science, Centre for Medical Image Computing, London, United Kingdom; 2 Institute of Neurology, Dementia Research<br />
Centre, London, United Kingdom<br />
2239. T 2 Alterations in Ex Vivo Human Brains with Alzheimer's Disease Pathology<br />
Robert J. Dawe 1 , Julie A. Schneider 2 , David A. Bennett 2 , Konstantinos Arfanakis 1<br />
1 Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States; 2 Rush Alzheimer's Disease<br />
Center, Rush University Medical Center, Chicago, IL, United States<br />
2240. Quantitative R 2 ' Mapping to Investigate <strong>the</strong> Relationship of Brain Iron Deposition & Cognitive Impairment in<br />
Alzheimer Disease<br />
Wenzhen Zhu 1 , Lingyun Zhao<br />
1 Department of Radiology, Tongji Hospital,Tongji Medical College, Wuhan, Hubei Province, China, People's Republic of<br />
2241. Automatic Segmentation of <strong>the</strong> Hippocampus in T 1 -Weighted MRI with Multi-Atlas Label Fusion using Open<br />
Source Software: Evaluation in 1.5 & 3.0T ADNI MRI<br />
Jung Wook Suh 1 , Hongzhi Wang 1 , Sandhitsu Das 1 , Brian Avants 1 , Paul A. Yushkevich 1<br />
1 PICSL, Radiology, University of Pennsylvania, Philadelphia, PA, United States<br />
2242. Magnetization Transfer Contrast (MTC) MRI for <strong>the</strong> Detection of Amyloid Accumulation in Alzheimer’s<br />
Disease<br />
Carlos J. Pérez-Torres 1,2 , Robia G. Pautler 1,2<br />
1 Interdepartmental <strong>Program</strong> in Translational Biology & Molecular Medicine, Baylor College of Medicine, Houston, TX, United<br />
States; 2 Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, United States<br />
2243. Patterns of White Matter Tract Damage in Behavioural Variant of Frontotemporal Dementia & Primary<br />
Progressive Aphasia: A DT MRI Study.<br />
Elisa Scola 1 , Federica Agosta 2 , Elisa Canu 2 , Lidia Sarro 2 , Alessandra Marcone 3 , Chiara Cerami 3 , Giuseppe Magnani 4 ,<br />
Francesca Caso 4 , Stefano Francesco Cappa 3,5 , Massimo Filippi 2 , Andrea Falini 1,6<br />
1 Neuroradiology - CERMAC, San Raffaele Scientific Institute, Milan, Italy; 2 Neuroimaging Research Unit, Scientific Institute &<br />
University San Raffaele Hospital, Milan, Italy; 3 San Raffaele Turro Hospital, Department of Clinical Neurosciences, Milan, Italy;<br />
4 Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute & University San<br />
Raffaele Hospital, Milan, Italy; 5 Vita Salute University & Department of Clinical Neurosciences, San Raffaele Scientific Institute,<br />
Milan, Italy; 6 Vita Salute University, San Raffaele Scientific Institute, Milan, Italy<br />
MRS of Animal Brain (except Cancer)<br />
Exhibition Hall Wednesday 13:30-15:30<br />
2244. Combined 1 H MRS & Near-Infrared Spectroscopy Measurements of Cerebral Blood Volume, Oxygenation,<br />
Cytochrome Oxidase & Intracellular Metabolites During Perinatal Hypoxia-Ischaemia<br />
Alan Bainbridge 1 , Ilias Tachtsidis 2 , Stuart Faulkner 3 , Sonya Mahony 2 , David Price 1 , David .L Thomas 4 , Ernest B.<br />
Cady 1 , Nicola J. Robertson 3 , Xavier Golay 4<br />
1 Medical Physics & Bioengineering, UCLH NHS Foundation Trust, London, United Kingdom; 2 Department of Medical Physics &<br />
Bioengineering, University College London, London, United Kingdom; 3 Institute for Women’s Health, UCL, London, United<br />
Kingdom; 4 Institute of Neurology, UCL, United Kingdom<br />
2245. Can 1 H MRS Be a Surrogate for 31 P MRS in Quantification of Transient Hypoxic-Ischemic Insult Severity in a<br />
Neonatal Encephalopathy Model?<br />
245