<strong>Poster</strong> Sessions 1 Bioquimica i Biologia Molecular, Universitat Autònoma Barcelona, Cerdanyola del Vallès, Barcelona, Spain; 2 Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Cerdanyola del Vallès, Barcelona, Spain; 3 Servei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona, Cerdanyola del Valles, Barcelona, Spain 979. Can T 1 or T 2 -Weighted MRI Measurements Detect Irreversible Electroporation Ablation Zones in Liver Tumors? Yue Zhang 1,2 , Yang Guo 2 , Jodi Nicolai 2 , Rachel A. Klein 2 , Reed A. Omary 2,3 , Andrew C. Larson 2,3 1 Bioengineering, University of Illinois at Chicago, Chicago, IL, United States; 2 Radiology, Northwestern University, Chicago, IL, United States; 3 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United States 980. Multi-Parametric MRI Assessment of <strong>the</strong> Anti-Angiogenic Effects of Liposome-Encapsulated Glucocorticoids Ewelina Kluza 1 , Marieke Heisen 2 , Sophie Schmid 1 , Daisy W. J. van Der Schaft 3 , Raymond M Schiffelers 4 , Gert Storm 4 , Bart M. ter Haar Romeny 2 , Gustav J. Strijkers 1 , Klaas Nicolay 1 1 Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Ne<strong>the</strong>rlands; 2 Biomedical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Ne<strong>the</strong>rlands; 3 Biomechanics & Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Ne<strong>the</strong>rlands; 4 Department of Pharmaceutical Sciences, Utrecht University, Utrecht, Ne<strong>the</strong>rlands 981. High Resolution Pre-Clinical MRI in Murine Braf-Induced Thyroid Tumor Targeted Therapy Aime T. Franco 1 , Ronald A. Ghossein 2 , H. Carl Le 3 , Jason A. Koutcher, 4 , Jame Fagin 5 1 Medicine & Human Human Oncology & Pathogenesis <strong>Program</strong>, MSKCC, New York, NY, United States; 2 Pathology, MSKCC, New York, NY, United States; 3 Medical Physics, MSKCC, New York, NY, United States; 4 Medicine, MSKCC; 5 Medicine & Human Oncology & Pathogenesis <strong>Program</strong>, MSKCC 982. A Multifunctional Nanoparticle Platform for Imaging Guided Therapy of Cancer Anita Gianella 1,2 , Peter A. Jarzyna 1 , Venkatesh Mani 1 , Sarayu Ramachandran 1 , Claudia Calcagno 1 , Gert Storm 3 , David P. Cormode 1 , Victor L. Thijssen 4 , Arjan W. Griffioen 4 , Zahi A. Fayad 1 , Willem J. M. Mulder 1 1 Translational & Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, United States; 2 Centro Cardiologico Monzino, Milano, Italy; 3 Utrecht Institute for Pharmaceutical Science, Utrecht, Ne<strong>the</strong>rlands; 4 Department of Medical Oncology, VU University Medical Center, Amsterdam, Ne<strong>the</strong>rlands 983. Evaluation of Gemcitabine as an Alternative Treatment to Temozolomide for High Grade Gliomas. Benjamin Lemasson 1 , Stefanie Galbán 2 , Terence M.Willians 2 , Fei Li 1 , Kevin A. Heist 1 , Timothy D. Johnson 3 , Alnawaz Rehemtulla 1,2 , Craig J. Galbán 1 , Brian Dale Ross 1 1 Radiology, University of Michigan, Ann Arbor, MI, United States; 2 Radiation Oncology, University of Michigan, Center for Molecular Imaging, Ann Arbor, MI, United States; 3 Biostatistics, University of Michigan, Ann Arbor, MI, United States 984. Comparison of Response to OXi4503 Therapy in Subcutaneous & Orthotopic Liver Metastasis Models using Susceptibility & Diffusion MRI Peter Johnson 1 , Simon Walker-Samuel 2 , Vineeth Rajkumar 3 , Ma<strong>the</strong>w Robson 3 , Mark F. Lythgoe* 2 , Barbara Pedley* 3 1 Institute of Cancer, University College London, London, United Kingdom; 2 UCL Centre for Advanced Biomedical Imaging, Department of Medicine & Institute of Child Health, University College London, London, United Kingdom; 3 Institute of Cancer, University College London, United Kingdom 985. Combining DCE-MRI & DW-MRI for Evaluating <strong>the</strong> Early Response of a Hypoxia-Activated Chemo<strong>the</strong>rapy Julio Cardenas 1 , Yuguo Li 2 , Christine a Howison 3 , Jean-Philippe Galons 4 , Amanda F Baker 5 , Mark D Pagel 6 1 Chemistry & Biochemistry, University of Arizona, Tucson, AZ, United States; 2 Radiology, Case Western Reserve University, Cleveland, OH, United States; 3 Arizona Research Laboratories, University of Arizona, Tucson, AZ, United States; 4 Radiology, University of Arizona, Tucson, AZ, United States; 5 Hematology/Oncology, Arizona Cancer Center, University of Arizona, Tucson, AZ, United States; 6 Biomedical Engineering & Chemistry & Biochemistry, University of Arizona, Tucson, AZ, United States 986. Integration of Diffusion Weighted Magnetic Resonance Imaging Data Into a Simple Ma<strong>the</strong>matical Model of Tumor Growth Nkiruka C. Atuegwu 1 , Daniel C. Colvin 1 , Mary E. Loveless 1,2 , Lei Xu 3 , John C. Gore 1,4 , Thomas E. Yankeelov 1,4 1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2 Biomedical Engineering, Vanderbilt University, Nashville, TN, United States; 3 Biostatistics, Vanderbilt University, Nashville, TN, United States; 4 Radiology, Vanderbilt University, Nashville, TN, United States 987. Native T 1 is a Generic Imaging Biomarker of Response to Chemo<strong>the</strong>rapy in Neuroblastoma Yann Jamin 1 , Elizabeth R. Cullis 2 , Lynsey Vaughan 2 , Hannah Webber 2 , Jessica K. R. Boult 1 , Lauren C. Baker 1 , Dow- Mu Kow 1 , Louis Chesler 2 , Simon P. Robinson 1 1 CRUK & EPSRC Cancer Imaging Centre, The Institute of Cancer Research & Royal Marsden NHS Trust, Sutton, United Kingdom; 2 Paediatric Oncology, The Institute of Cancer Research, Sutton, United Kingdom 128
<strong>Poster</strong> Sessions 988. The Effect of Cediranib on <strong>the</strong> Vascular Structure & Function of C 6 Rat Xenografts with Combined Carbogen USPIO (CUSPIO) Imaging Jake Samuel Burrell 1 , Jane Halliday 2 , Simon Walker-Samuel 3 , Jessica K. R. Boult 1 , Yann Jamin 1 , John C. Waterton 2 , Simon P. Robinson 1 1 The Institute of Cancer Research, Sutton, Surrey, United Kingdom; 2 AstraZeneca, Manchester, United Kingdom; 3 Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom 989. Assessment of Early Treatment Response using a Fast & Robust MRI Protocol in Genetically Engineered Mouse Lung Cancer Models Yanping Sun 1 , Juan Wang 1 , Amy M. Saur 1 , Zandra Walton 2 , Val Monrose 1 , Kwok-Kin Wong 2 , Andrew L. Kung 1,3 1 Lurie Family Imaging Center, Dana-Farber Cancer Institute & Harvard Medical School, Boston, MA, United States; 2 Department of Medical Oncology, Dana-Farber Cancer Institute & Harvard Medical School, Boston, MA, United States; 3 Pediatric Oncology, Children's Hospital Boston, Boston, MA, United States 990. Proton & Sodium MRI Follow-Up of Human Colorectal Tumors Implanted in Mice. Comparison between Two Photodynamic Therapy Protocols. Carole Danielle Thomas 1,2 , Florent Poyer 1,2 , Philippe Maillard 2,3 , Andreas Volk 1,2 , Guillaume Garci 2,3 , Alain Croisy 1,2 , Mihaela Lupu 1,2 , Joel Mispelter 1,2 1 Research, Curie Institute/INSERM U759, Orsay, France, Metropolitan; 2 University Paris XI, Orsay, France, Metropolitan; 3 Research, Curie Institute/CNRS UMR176, Orsay, France, Metropolitan 991. EPR Study of <strong>the</strong> Tumor Reoxygenation Following Inhibition of <strong>the</strong> MAPKinase Pathway: Underlying Mechanisms & Radiosensitizing Effects Oussama Karroum 1 , Julie Kengen 1 , Pierre Danhier 1 , Julien Verrax 2 , Pedro Buc Calderon 2 , Pierre Sonveaux 3 , Vincent Gregoire 4 , Bernard Gallez 1 , Benedicte F. Jordan 1 1 Louvrain Drug Research Institute, Biomedical Magnetic Resonance Group, Universite Catholique de Louvain, Brussels, Belgium; 2 Louvrain Drug Research Institute, Pharmacokinetics, Metabolism, Nutrition, & Toxicology Group, Universite Catholique de Louvain; 3 IREC, Pole of Pharmacology & Therapeutics, Universite Catholique de Louvain; 4 IREC, Molecular Imaging & Radio<strong>the</strong>rapy, Universite Catholique de Louvain 992. In Vivo MRI of Rat Thyroid Glands for Non-Invasive Virtual Histopathology Basil Künnecke 1 , Barbara Lenz 1 , Markus Stephan-Güldner 1 , Anna Maria Brändli-Baiocco 1 , Jürgen Funk 1 , Thomas Pfister 1 , Markus von Kienlin 1 1 Pharmaceuticals Division, F. Hoffmann-La Roche Ltd, Basel, Switzerland 993. Early Response Assessment Treatment in Metastatic Prostate Cancer to <strong>the</strong> Bone using Diffusion MRI. Jean-Christophe Brisset 1 , Stefanie Galbán 2 , Alnawaz Rehemtulla 2 , Kenneth James Pienta 3 , Craig J. Galbán 1 , Brian Dale Ross 1 1 Radiology, University of Michigan, Ann Arbor, MI, United States; 2 Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States; 3 Department of Internal Medicine & Urology, University of Michigan, Ann Arbor, MI, United States 994. Multiparametric MR Mapping of Tissue Response to Photodynamic Therapy in an Intramuscular Model of Murine Squamous Cell Carcinoma Mirabelle Sajisevi 1,2 , David A. Bellnier 3 , Nestor Rigual 2 , Mukund Seshadri 1,4 1 Preclinical Imaging Facility, Roswell Park Cancer Institute, Buffalo, NY, United States; 2 Head & Neck Surgery, Roswell Park Cancer Institute, Buffalo, NY, United States; 3 Cell Stress Biology, Roswell Park Cancer Institute; 4 Pharmacology & Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, United States Cancer - Cells, Biopsies & Biofluids Exhibition Hall Thursday 13:30-15:30 995. Inhibition of Phosphatidylcholine-Specific Phospholipase C Induces Down-Regulation of CXCR4 Overexpression & Reduction of 1 H-MRS-Detected PCho in Human Lymphoblastoid Cells Alessandro Ricci 1 , Serena Cecchetti 1 , Maria Elena Pisanu 1 , Luisa Paris 1 , Luigi Portella 2 , Stefania Scala 2 , Egidio Iorio 1 , Franca Podo 1 1 Cell Biology & Neurosciences, Istituto Superiore di Sanità, Rome, RM, Italy; 2 Department of Clinical Immunology, National Cancer Institute, Naples, NA, Italy 996. Effects of Downmodulation of Choline Kinase on MRS Choline Profile & Transcriptome in Ovarian Cancer Cells Anna Granata 1 , Egidio Iorio 2 , Maria Teresa Comito 1 , Alessandro Ricci 2 , Maria Elena Pisanu 2 , Zaver M. Bhujwalla 3 , Franca Podo 2 , Silvana Canevari 1 , Delia Mezzanzanica 1 , Marina Bagnoli 1 129
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