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Download the 2011 Program Book - Traditional Poster ... - ismrm

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<strong>Poster</strong> Sessions<br />

1529. Pulsed Arterial Spin Labelling Perfusion Imaging at 3T: Estimating <strong>the</strong> Number of Subjects Required in<br />

Common Designs of Clinical Trials<br />

Kevin Murphy 1 , Ashley D. Harris 1 , Ana Diukova 1 , Christopher John Evans 1 , David J. Lythgoe 2 , Fernando Zelaya 2 ,<br />

Richard G. Wise 1<br />

1 CUBRIC, School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom; 2 King’s College London, Institute of<br />

Psychiatry, Centre for Neuroimaging Sciences, DeCrespigny Park, Denmark Hill, London, United Kingdom<br />

1530. Approximating Water Exchange In Vivo in a Rat Model<br />

Colleen Bailey 1,2 , Firas Moosvi 1,2 , Greg J. Stanisz 1,2<br />

1 Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2 Medical Biophysics, University of Toronto, Toronto, ON, Canada<br />

1531. The Impact of Water Exchange on Dynamic Contrast Enhanced MRI: Can We Estimate Tissue Water<br />

Residence Times In Vivo?<br />

Lauren Jean Bains 1,2 , Josephine H. Naish 1,2 , David L. Buckley 3<br />

1 Imaging Sciences Research Group, University of Manchester, Manchester, Greater Manchester, United Kingdom; 2 Biomedical<br />

Imaging Institute, Manchester, Greater Manchester, United Kingdom; 3 Division of Medical Physics, University of Leeds, Leeds,<br />

United Kingdom<br />

1532. Correction of Base-Line [Gd] Offsets Due to Effective Saturation Pulse Flip-Angle Variations in 3T Liver DCE-<br />

MRI<br />

Andrew Brian Gill 1,2 , Andrew N. Priest 2 , Richard T. Black 1 , David J. Bowden 2 , Martin J. Graves 2 , David J. Lomas 2<br />

1 Medical Physics, Addenbrooke's Hospital, Cambridge, United Kingdom; 2 Radiology, University of Cambridge, Cambridge, United<br />

Kingdom<br />

Drug Discovery<br />

Exhibition Hall Thursday 13:30-15:30<br />

1533. Pharmacological MRI with Continuous ASL in Conscious Rats: Characterizing <strong>the</strong> Relationship Between CBF<br />

Response to CNS Compounds & Plasma Concentration Levels<br />

Alexandre Coimbra 1 , Denise Welsh 1 , Diane Posavec 1 , Amy Vanko 1 , Richard Baumgartner 2 , Christopher Regan 3 ,<br />

Andrew Danziger 3 , Mat<strong>the</strong>w Baran 3 , Kristina Groover 3 , Jacquelynn Cook 1 , Joseph Lynch 3 , Jason Uslaner 3 , Donald<br />

Williams 1<br />

1 Imaging, Merck & Co, Inc, West Point, PA, United States; 2 Biometrics, Merck & Co, Inc, Rahway, NJ, United States; 3 Central<br />

Pharm, Merck & Co, Inc, West Point, PA<br />

1534. Assessment of DCEMRI with Gadoxetate as a Biomarker of Drug Induced Cholestasis<br />

Jose Ulloa 1 , Simone Stahl 2 , Neil Woodhouse 1 , Guy Healing 2 , Gerry Kenna 2 , John C. Waterton 1 , Paul Hockings 1<br />

1 Translational Sciences, AstraZeneca, Macclesfield, Cheshire, United Kingdom; 2 Safety Assessment, AstraZeneca, Macclesfield,<br />

Cheshire, United Kingdom<br />

1535. Antibiotic Minocycline Suppressess <strong>the</strong> PhMRI Response to Acute Ketamine Challenge<br />

Duncan Jack Hodkinson 1 , Diana Cash 2 , Steve C. R. Williams 2 , Shane McKie 3 , John Francis W. Deakin 3 , Steve R.<br />

Williams 1<br />

1 Imaging Science & Biomedical Engineering, University of Manchester, Manchester, United Kingdom; 2 Neuroimaging Research<br />

Group, Institute of Psychiatry, King's College London, London, United Kingdom; 3 Neuroscience & Psychiatry Unit, University of<br />

Manchester, Manchester, United Kingdom<br />

1536. In Vivo Target Analysis by MRI in a Murine Model of Pulmonary Fibrosis<br />

Nicolau Beckmann 1 , Anna L. Babin 2 , Christelle Gerard 1 , Ca<strong>the</strong>rine Cannet 1 , Helmut Sparrer 3 , Pierre Saint-Mezard 4 ,<br />

Gabor Jarai 5 , Tetsuya Matsuguchi 6<br />

1 Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland; 2 Sackler Institute of Pulmonary<br />

Pharmacology, Kings College London, London, United Kingdom; 3 Autoimmune Diseases Department, Novartis Institutes for<br />

BioMedical Research, Basel, Switzerland; 4 Developmental & Molecular Pathways Department, Novartis Institutes for BioMedical<br />

Research, Basel, Switzerland; 5 Respiratory Diseases Department, Novartis Institutes for BioMedical Research, Horsham, United<br />

Kingdom; 6 Department of Developmental Medicine, Kagoshima University Graduate School of Medical & Dental Sciences,<br />

Kagoshima, Japan<br />

1537. Cerebral Amyloid Angiopathy in APP 23 Mice Modelling Alzheimer’s Disease Studied Non-Invasively by MRI:<br />

Application to Passive Amyloid-Beta Immuno<strong>the</strong>rapy<br />

Nicolau Beckmann 1 , Christelle Gerard 1 , Doro<strong>the</strong>e Abramowski 2 , Ca<strong>the</strong>rine Cannet 1 , Matthias Staufenbiel 2<br />

1 Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland; 2 Neuroscience Discovery, Novartis<br />

Institutes for BioMedical Research, Basel, Switzerland<br />

180

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