Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
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First remarks<br />
• Many of the papers (especially in the US) still rely<br />
on the Prentice Criteria for validation<br />
• Several papers are based on non randomized<br />
cohorts<br />
• Validity specific to<br />
• Disease stage<br />
• Form of summary statistic (eg: <strong>PSA</strong>-DT vs <strong>PSA</strong><br />
response for HRPC on Taxotere)<br />
• Treatment mechanism of action (HR vs Taxotere vs<br />
Other drugs)