Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped

Prostate cancer (PCa)
• PCa is a cancer that affects older men (above 50, with
peak incicence around age 70)
• It is a very frequent disease: one in every 6 men will
some day be diagnosed with prostate cancer (PCa)
(Jemal et al. Cancer statistics 2003)
• But it is a very slowly growing disease: PCa accounts
for only 4% of all male deaths (SEER 1973-95)
• PCa is an hormone sensitive disease, the mainstay of
its treatment consists in androgen ablation.