Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
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Treatment effects on OS against treatment effects<br />
on Time to <strong>PSA</strong> Progression (50% rise)<br />
-0.5<br />
Effect on<br />
survival<br />
(log HR)<br />
-0.5<br />
0.0<br />
0.5<br />
1.0<br />
-0.5<br />
R 2 trial<br />
= 0.66 (CI: 0.3 – 0.85)<br />
Moderate trial-unit correlation<br />
Effect on TTPP-2 (log HR)<br />
Within patient: concordance coefficient τ = 0.61 (SE=0.02)