Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Treatment effects on OS against treatment effects<br />
on Time to <strong>PSA</strong> Progression (20% rise)<br />
Effect on<br />
survival<br />
(log HR)<br />
1.0<br />
-0.5 0.0 0.5 1.0 1.5<br />
-1.0<br />
2.0<br />
-2.0<br />
-3.0<br />
-4.0<br />
R 2 trial<br />
= 0.21 (CI: 0 – 0.56)<br />
Low trial-unit correlation<br />
-5.0<br />
Effect on TTPP-1 (log HR)<br />
Within patient: concordance coefficient τ = 0.52 (SE=0.004)