Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
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4m vs 24m ADT adjuvant to irradiation of<br />
locally advanced PCa (RTOG 92-02)<br />
T2c-T4<br />
PreRx <strong>PSA</strong><br />
< 150 ng/ml<br />
R<br />
A<br />
N<br />
D<br />
O<br />
M<br />
I<br />
Z<br />
E<br />
Arm 1: goserelin and flutamide 2 mos<br />
before and during standard RT (STAD)<br />
1554 patients<br />
448 deaths<br />
145 of PC<br />
Arm 2: goserelin and flutamide 2 mos before<br />
and during standard RT, followed by goserelin<br />
alone for 24 mos (LTAD)<br />
Ref: Valicenti RK et al. Int J Rad Oncol Biol Phys 2006
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