Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
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<strong>PSA</strong> doubling-free survival (<strong>PSA</strong>-D) as a surrogate<br />
for progression-free survival in M0 hormone<br />
sensitive patients (EPC program)<br />
1.0<br />
Log HR for PFS<br />
0.5<br />
0<br />
-0.5<br />
-1.0<br />
◦ = region<br />
-1.5<br />
-2.0<br />
-2.0 -1.5 -1.0 -0.5 0 0.5 1.0<br />
Log HR for <strong>PSA</strong>-D free survival<br />
R²=0.69, p=0.001<br />
Newling et al, ASCO 05
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