Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
Surrogacy Case Study: Prostate Specific Antigen (PSA ... - Isped
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Prediction for a new trial – M1<br />
• R² trial for time to <strong>PSA</strong> progression (50% rise) is 0.66<br />
(95% CI:0.30 – 0.85)<br />
• Assuming a new study of 400 events leading to a HR<br />
for <strong>PSA</strong> of 0.50 (Z=-6.9, P=