Chitosan Loaded Mucoadhesive Microspheres of Gliclazide - Journal

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CONCLUSION Methods A, B and C for the estimation of Pramipexole in tablet dosage form were found to be simple, accurate. Beer- Lambert's law was obeyed in the concentration range of 9- 45µg/ml for the three methods. The values of standard deviation were satisfactory. As the drug Pramipexole showed a broad spectrum, the derivative spectroscopy method applied has advantage that it locates the hidden peaks in the normal spectrum when the spectrum is not sharp and it also eliminates the interference caused by the excipients and the degradation products present, if any, in the formulation. The AUC method is also advantageous as it is applicable to the drugs which show the broad spectra without a sharp peak. Hence these methods can be useful in the routine analysis of Pramipexole in bulk drug and formulations. ACKNOWLEDGEMENT We are thankful to Sun Pharmaceuticals Ltd, Jammu and Kashmir for providing us the gift sample of the pure drug and to the Principal, H.K.E.Society's college of pharmacy, Gulbarga for providing research facilities. REFERENCES Shobha Manjunath et al./ A Novel Spectrophotometric Estimation of Pramipexole in Bulk Drug and Formulations 1. McCormack PL, Siddiqui MAA, CNS drugs.2007;21(5):p.429-37. 110 2. Mierau J, Schneider FJ, Ensinger HA, Chio CL, Lajiness ME, Huff RM. Eur j pharmacol.1995;290(1):29-36. 3. O' Neil M.J, editor. The Merck Index: An Encyclopedia of Chemicals, th Drug and Biologicals. 14 ed. Merck & Co. Inc 2006; 7707. th 4. Sweetman SC, editor. Martindale: The Complete Drug Reference, 35 ed. London: Pharmaceutical press.2007:731. 5. Lau YY, Hanson GD, Ichhpurani N. J.chromatography. B Biomed Appl 1996;638(2): 217-23. 6. Lau YY, Hanson GD, Ichhpurani N, Selenka JM, Talaat R. J Chromatogr. B.Biomed.Appl. 1996; 638(2): 209-16. 7. Jancic B, Medenica M, Ivanovic D, Malenovic A. Chromatographia. 2007;65(9-10): 633-5. 8. VLN.SeshagiriRao J, Anantha Kumar D, Shaik mastanamma, Srilakshmi K. Int.J.Chem.sci. 2009;7(4):2789-94. 9. Gurupadayya BM, Vishwajith V, Srujana N. World j chem. 2009; 4(2):157-60. Address for Correspondence Shobha Manjunath, Department of Pharmaceutical Analysis, H.K.E. Society's College of Pharmacy, Gulbarga- 585105, Karnataka, India E-mail: Shobamanjunath8@gmail.com RJPS, Jul - Sep, 2011/ Vol 1/ Issue 2
A B S T R A C T RGUHS Journal of Pharmaceutical Sciences Validated UV-Spectrophotometric Estimation of Entecavir in Bulk and Formulations Malipatil S.M*, Bharath S Athanikar and Mogal Dipali Original Research Article Department of Pharmaceutical Analysis, H.K.E.S's Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Gulbarga-585105, Karnataka, India Three new, simple and cost effective UV-spectrophotometric methods were developed for the estimation of Entecavir in bulk and pharmaceutical formulations. Entecavir was estimated at 253.6 nm in UV-spectroscopic method (Method A), 242.6 nm in first order derivative spectroscopy (Method B) and scanned at 258.0 - 248.0 nm in Area Under Curve method (Method C). Linearity range was 2 2 2 found to be 2-18 μg/ml (Correlation coefficient r = 0.9999 in method A, r = 0.9999 in method B and r = 0.9998 in method C) in all the three 4 -1 -1 4 -1 -1 4 -1 methods. The molar absorptivity was found to be 1.5x10 L mol cm in method A, 1.108X10 L mol cm in method B and 3.17x10 L mol -1 cm in in method C. These methods were tested and validated for various parameters according to ICH guidelines. The proposed methods were successfully applied for the determination of Entecavir in pharmaceutical formulation (tablets). The results demonstrated that the procedure is accurate, precise and reproducible (% relative standard deviation
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R G U H S Dr. Amit Agarwal, India D
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