Chitosan Loaded Mucoadhesive Microspheres of Gliclazide - Journal

RGUHS Journal of Pharmaceutical Sciences
Assessment of Safety and Efficacy of Doxycycline and Azithromycin
Preparations in Patients with Acne Vulgaris
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Mahendra Kumar B.J*, Ramakrishna S , Kranti Basavant Patil, Sandeep A, Bhimaray S Krishnagoudar and
Katti Ravi Venkappa.
A B S T R A C T
Clinical Pharmacy Department, S A C College of Pharmacy, B.G.Nagara-571448, Karnataka
1 Principal, CR College of Pharmacy, Koratagere, Tumkur, Karnataka
INTRODUCTION
Acne vulgaris is a chronic inflammatory dermatosis which is
notable for open and/ or closed comedones (blackheads and
whiteheads) and inflammatory lesions including papules,
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pustules, or nodules. Acne vulgaris is the most common skin
disorder in the United States, affecting 40 to 50 million
people. Acne vulgaris affects approximately about 80% of the
total population between the age of 12 to 25 years, with no
gender, race, or ethnicity prevalence. Acne depending on the
ages varies and usually begins at puberty. A form of acne
called adult acne may first occur after the mid 20s, affecting
females more than males, and with lesions generally
distributed in the lower facial area around the mouth, chin
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and jaw line.
Localization of acne vulgaris on the facial area, especially in
adolescent population, significantly impacts self-esteem.
Although acne is self limiting, it can persist for years and can
result in disfigurement and scarring. Acne may also be
associated with anxiety, depression, and higher than average
unemployment rates. As the emotional impact of acne is not
always easy to assess clinically, it is important for the health
care professionals to educate patients on various causes of
acne, discussing treatment regimens, and counseling on
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proper medication use.
RGUHS Journal of Pharmaceutical Sciences
Received: 27/1/2011, Modified: 27/2/2011, Accepted: 4/3/2011
131
Original Research Article
Acne vulgaris is the most common skin disease, affects 80% of population between the age of 12 and 25 years with no gender, race or
ethnicity prevalence. Oral and topical agents advocated for the treatment. Antibiotics are the mainstay of acne treatment. The objective
of the study is to assess efficacy and safety of azithromycin and doxycycline with topical clindamycin for patients with acne vulgaris. This
study is a prospective, observational, investigational and randomisation study carried out in Dermatology department of a tertiary care
teaching hospital in a north Karnataka for a period of 8 months. Patients enrolled in the study were divided in to two groups- Group-I and
Group-II. The Group-I received Tablet Azithromycin 500 mg with Topical Clindamycin where Group-II received Tablet Doxycycline 100
mg with Topical Clindamycin. Clinical assessment was done at 30 days interval for 3 months. The mean severity index of Group-I
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declined from 113.36 to 09.92 at 3 follow-up and Group-II from 107.32 to 28. In Group-I out of 25 patients 2 patients reported ADR where
from Group-II out of 25 patients 6 patients reported ADR.
Keywords: Acne vulgaris, Azithromycin, Doxycycline, efficacy and safety assessment.
Antibiotics are a main stay of acne treatment, and
clindamycin phosphate is the most widely used topical
antibacterial agent. Although there are several effective
therapies for acne vulgaris, lack of adherence to the treatment
regimen is believed to contribute to treatment failure or less
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than optimal result.
There are number of oral antibiotics that are used to treat
acne including minocycline, tetracycline, and doxycycline.
The efficacy and possible side effects of these various oral
antibiotics has been the subject of numerous studies for at
least the last 20 years in an effort to understand, which
products are likely to produce better results with the least
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amount of possible side effects.
While effective therapeutic options exist for the treatment of
acne, treatment compliance with acne medications has been
shown to be as low as 12.5%. In fact poor patient compliance
has been identified as the main reason for acne treatment
failure. Accurate diagnosis, appropriate therapy and good
compliance with directions for therapy are all important
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components in the treatment of disease.
Antibiotics used for the treatment of acne vulgaris are
associated with some of the mild to severe side effects and
require interventional studies to compare the efficacy and
safety profiles of these medications to ensure the safe usage of
medications. Therefore, this study is being conducted to assess
the efficacy and safety of azithromycin and doxycycline with
topical clindamycin for patients with acne vulgaris.
RJPS, Jul - Sep, 2011/ Vol 1/ Issue 2