Chitosan Loaded Mucoadhesive Microspheres of Gliclazide - Journal

patients had lesions on the face, 47.16%of the patients had
acne on the back also and 35.84%had lesions on the chest.
Lesion distribution varies with individuals and there is no
definite pattern of lesion distribution described.
Clinical assessment of Acne
Different grading methods have been used for measuring the
severity of acne, but to date, a widely accepted standardised
classification system does not exist. In the present study, in all
the cases the acne lesions were graded according to severity
index described by Michaelsson et al by counting the number
of open or closed comedones (0.5), papules (1), pustules (2),
and infiltrated lesions (3) and cystic lesions (4). The total
severity score of disease was calculated by multiplying each
type of lesion with its severity index and adding them together.
Efficacy Assessment
In a study it was found that a combination of azithromycin
and topical clindamycin was significantly better than
doxycycline and topical clindamycin in the treatment of
inflammatory acne vulgaris. In this study there was 91.25%
improvement in group I (Azithromycin group) in comparison
to 73.91% improvement in group II (Doxycycline group) and
this difference was statistically significant by 'ANOVA' test
(p