Chitosan Loaded Mucoadhesive Microspheres of Gliclazide - Journal

Sikarwar Mukesh S et al./ Antihyperlipidemic Effect of Ethanolic Extract of Hibiscus rosa sinensis Flowers in Hyperlipidemic Rats
Table 1: Effect of Hibiscus rosa sinensis ethanolic extract on serum total cholesterol, triglycerides and phospholipids level in triton-induced hyperlipidemic rats
a
Gro Treatment Values are expressed as mg/dl, Mean±SEM
up Cholesterol Triglycerides Phospholipids
6 hr 24 hr 48 hr 6 hr 24 hr 48 hr 6 hr 24 hr 48 hr
I Normal control 60.83±1.327 68.17 ±1.701 64.66±1.54 2 65.33±2.140 67.16±2.023 64.83±1.701 75.5±3.304 78.33±0.918 74±1.366
(vehicle only)
II Hyperlipidemic 106.5±4.089 260.33±5.925 178.5±3.649 101 ±3.000 208.66±5.469 107.83±3.208 106.5±2.3 20 185.83±2. 600 100.83±2. 482
control
III Simvastatin 83.67±1.838 ** 176.17±7.56 9** 73.83±2.82 2** 81.5±1.746 ** 172.5±3.631** 79.66±3.981** 91.66±1.7 26** 139.66±1. 333** 80.33±1.4 06**
10mg/kg
IV Ethanolic extract 87.33±3.333 ** 186.16±3.20 8** 81±1.932** 85.16±1.956** 175±3.088 83.33±2.186 ** 92.33±1.9 26* 135.83±3. 816** 86±2.769* *
500mg (EEHRS)
a * **
mg/kg/day for 48 hrs. Values are means±SEM; N=6. Values are statistically significant at P